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Physical and functional interactions between Daxx and STAT3.
| Title: | Physical and functional interactions between Daxx and STAT3. |
| Authors: | Muromoto, R. Browse this author | | Nakao, K. Browse this author | | Watanabe, T. Browse this author | | Sato, N. Browse this author | | Sekine, Y. Browse this author | | Sugiyama, K. Browse this author | | Oritani, K. Browse this author | | Shimoda, K. Browse this author | | Matsuda, T. Browse this author →KAKEN DB |
| Keywords: | IL-6 | | LIF | | STAT3 | | Daxx | | transcriptional regulation |
| Issue Date: | 30-Mar-2006 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Oncogene |
| Volume: | 25 |
| Issue: | 14 |
| Start Page: | 2131 |
| End Page: | 2136 |
| Publisher DOI: | 10.1038/sj.onc.1209235 |
| PMID: | 16331268 |
| Abstract: | Signal transducer and activator of transcription 3 (STAT3) play key roles in the intracellular signaling pathways of the interleukin (IL)-6 family of cytokines, which exhibit a diverse set of cellular responses, including cell proliferation and differentiation. Dysregulated IL-6/STAT3 signaling is involved in the pathogenesis of several diseases, for example autoimmune diseases and tumors. Type I interferon (IFN) induces the expression of proapoptotic genes and has been used in the clinical treatment of several tumors. In the present study, we found that type I IFN suppressed IL-6/STAT3-mediated transcription and gene expression. Furthermore, a type I IFN-induced protein, Daxx, also suppressed STAT3-mediated transcriptional activation, while overexpression of Daxx inhibited IL-6/STAT3-mediated gene expression. Importantly, small-interfering RNA-mediated reduction of Daxx expression enhanced IL-6/leukemia inhibitory factor (LIF)-induced STAT3-dependent transcription. Co-immunoprecipitation studies revealed a physical interaction between Daxx and STAT3 in transiently transfected 293T cells. We further found that Daxx and STAT3 were co-localized in the nucleus. These results indicate that Daxx may serve as a transcriptional regulator of type I IFN-mediated suppression of the IL-6/STAT3 signaling pathway. |
| Rights: | Nature Publishing Group, ONCOGENE, 25, 14, 2006, 2131-2136. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/22103 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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