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Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

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Title: Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Authors: Ito, Kiyoharu Browse this author
Anada, Yoshihiro Browse this author
Tani, Motohiro Browse this author
Ikeda, Mika Browse this author
Sano, Takamitsu Browse this author →KAKEN DB
Kihara, Akio Browse this author →KAKEN DB
Igarashi, Yasuyuki Browse this author →KAKEN DB
Keywords: Sphingosine 1-phosphate
Issue Date: 25-May-2007
Publisher: Elsevier Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 357
Issue: 1
Start Page: 212
End Page: 217
Publisher DOI: 10.1016/j.bbrc.2007.03.123
PMID: 17418101
Abstract: Platelets are known to store a large amount of the bioactive lipid molecule sphingosine 1-phosphate (S1P) and to release it into the plasma in a stimuli-dependent manner. Erythrocytes can also release S1P, independently from any stimuli. We measured the S1P and sphingosine (Sph) levels in erythrocytes by HPLC and found that the contribution of erythrocyte S1P to whole blood S1P levels is actually higher than that of platelets. In vitro assays demonstrated that erythrocytes possess much weaker Sph kinase activity compared to platelets but lack the S1P-degrading activities of either S1P lyase or S1P phosphohydrolase. This combination may enable erythrocytes to maintain a high S1P content relative to Sph. The absence of both S1P-degrading enzymes has not been reported for other cell types. Thus, erythrocytes may be specialized cells for storing and supplying plasma S1P.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木原 章雄

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