HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
情報科学研究科  >
雑誌発表論文等  >

Changes in the spontaneous calcium oscillations for the development of the preconditioning-induced ischemic tolerance in neuron/astrocyte co-culture.

フルテキスト
NR32-6.pdf512.85 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/25393

タイトル: Changes in the spontaneous calcium oscillations for the development of the preconditioning-induced ischemic tolerance in neuron/astrocyte co-culture.
著者: Tanaka, Motoki 著作を一覧する
Kawahara, Koichi 著作を一覧する
Kosugi, Tatsuro 著作を一覧する
Yamada, Takeshi 著作を一覧する
Mioka, Tetsuo 著作を一覧する
キーワード: Spontaneous Ca2+ oscillations
Ischemic tolerance
GLT-1
PACAP
Oxygen and glucose deprivation
Neuron/astrocyte co-cultures
発行日: 2007年 6月
出版者: Springer Netherlands
誌名: Neurochemical Research
巻: 32
号: 6
開始ページ: 988
終了ページ: 1001
出版社 DOI: 10.1007/s11064-006-9259-8
抄録: Spontaneous Ca2+ oscillations are believed to contribute to the regulation of gene expression. Here we investigated whether and how the dynamics of Ca2+ oscillations changed after sublethal preconditioning (PC) for PC-induced ischemic tolerance in neuron/astrocyte co-cultures. The frequency of spontaneous Ca2+ oscillations significantly decreased between 4 and 8 h after the end of PC in both neurons and astrocytes. Treatment with 2-APB, an inhibitor of IP3 receptors, decreased the oscillatory frequency, induced ischemic tolerance and a down-regulation of glutamate transporter GLT-1 contributing to the increase in the extracellular glutamate during ischemia. The expression of GLT-1 is known to be up-regulated by PACAP. Treatment with PACAP38 increased the oscillatory frequency, and antagonized both the PC-induced down-regulation of GLT-1 and ischemic tolerance. These results suggested that the PC suppressed the spontaneous Ca2+ oscillations regulating the gene expressions of various proteins, especially of astrocytic GLT-1, for the development of the PC-induced ischemic tolerance.
Rights: The original publication is available at www.springerlink.com
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/25393
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 河原 剛一

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学