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Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates

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Title: Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates
Authors: Natori, Yoshihiro Browse this author
Anada, Masahiro Browse this author →KAKEN DB
Nakamura, Seiichi Browse this author
Nambu, Hisanori Browse this author →KAKEN DB
Hashimoto, Shunichi Browse this author →KAKEN DB
Issue Date: 31-Dec-2006
Publisher: The Japan Institute of Heterocyclic Chemistry
Journal Title: Heterocycles - An International Journal for Reviews and Communications in Heterocyclic Chemistry
Volume: 70
Start Page: 635
End Page: 646
Abstract: A new, catalytic enantioselective route to 3-arylindan-1-ones, versatile intermediates for the synthesis of a number of bioactive and pharmaceutically interesting molecules, was developed by exploiting the chiral dirhodium(II) complex-catalyzed intramolecular C-H insertion reaction of α-diazo-β-ketoesters as a key step. Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, proved to be the catalyst of choice for this process, providing enantioselectivities of up to 72% ee.
Type: article (author version)
URI: http://hdl.handle.net/2115/26428
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 穴田 仁洋

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