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Hokkaido University Collection of Scholarly and Academic Papers >
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Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates
| Title: | Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates |
| Authors: | Natori, Yoshihiro Browse this author | | Anada, Masahiro Browse this author →KAKEN DB | | Nakamura, Seiichi Browse this author | | Nambu, Hisanori Browse this author →KAKEN DB | | Hashimoto, Shunichi Browse this author →KAKEN DB |
| Issue Date: | 31-Dec-2006 |
| Publisher: | The Japan Institute of Heterocyclic Chemistry |
| Journal Title: | Heterocycles - An International Journal for Reviews and Communications in Heterocyclic Chemistry |
| Volume: | 70 |
| Start Page: | 635 |
| End Page: | 646 |
| Abstract: | A new, catalytic enantioselective route to 3-arylindan-1-ones, versatile intermediates for the synthesis of a number of bioactive and pharmaceutically interesting molecules, was developed by exploiting the chiral dirhodium(II) complex-catalyzed intramolecular C-H insertion reaction of α-diazo-β-ketoesters as a key step. Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, proved to be the catalyst of choice for this process, providing enantioselectivities of up to 72% ee. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/26428 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 穴田 仁洋
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