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The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.

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Title: The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
Authors: Imoto, Seiyu Browse this author
Sugiyama, Kenji Browse this author
Yamamoto, Tetsuya Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: BMP
RING domain
Issue Date: 18-Jun-2004
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 319
Issue: 1
Start Page: 275
End Page: 282
Publisher DOI: 10.1016/j.bbrc.2004.04.161
PMID: 15158472
Abstract: Bone morphogenetic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Recently, we have demonstrated that a protein inhibitor of activated STAT, PIASy, suppresses TGF-β signaling by interacting with Sma and MAD-related protein 3 (Smad3). In this study, we examined a PIASy-dependent inhibitory effect on BMP signaling. PIASy expression was induced by BMP-2 stimulation and suppressed BMP-2-dependent Smad activity in hepatoma cells. Furthermore, BMP-2-regulated Smads directly bound to PIASy. We also demonstrated that the RING domain of PIASy played an important role in PIASy-mediated suppression of Smad activity. We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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