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The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.

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タイトル: The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
著者: Imoto, Seiyu 著作を一覧する
Sugiyama, Kenji 著作を一覧する
Yamamoto, Tetsuya 著作を一覧する
Matsuda, Tadashi 著作を一覧する
キーワード: BMP
Smad
RING domain
PIASy
Transcription
発行日: 2004年 6月18日
出版者: Elsevier
誌名: Biochemical and Biophysical Research Communications
巻: 319
号: 1
開始ページ: 275
終了ページ: 282
出版社 DOI: 10.1016/j.bbrc.2004.04.161
抄録: Bone morphogenetic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Recently, we have demonstrated that a protein inhibitor of activated STAT, PIASy, suppresses TGF-β signaling by interacting with Sma and MAD-related protein 3 (Smad3). In this study, we examined a PIASy-dependent inhibitory effect on BMP signaling. PIASy expression was induced by BMP-2 stimulation and suppressed BMP-2-dependent Smad activity in hepatoma cells. Furthermore, BMP-2-regulated Smads directly bound to PIASy. We also demonstrated that the RING domain of PIASy played an important role in PIASy-mediated suppression of Smad activity. We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain.
Relation (URI): http://www.sciencedirect.com/science/journal/0006291X
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/28116
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正

 

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