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Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

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Title: Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
Authors: Sekine, Yuichi Browse this author
Yamamoto, Tetsuya Browse this author
Yumioka, Taro Browse this author
Imoto, Seiyu Browse this author
Kojima, Hiroyuki Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: STAT3
Endocrine-disrupting chemicals
Estrogen receptor
Issue Date: 12-Mar-2004
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 315
Issue: 3
Start Page: 692
End Page: 698
Publisher DOI: 10.1016/j.bbrc.2004.01.109
PMID: 14975756
Abstract: STAT3 mainly acts as a signal transducer of IL-6 family cytokines and transcriptionally activates specific target genes. STAT3 has also been demonstrated to mediate cellular transformation and is found in numerous cancers. Endocrine-disrupting chemicals (EDCs) are a diverse group of chemicals that bind to estrogen receptors (ERs), mimic estrogenic actions, and may have adverse effects on human health. In our previous study, we demonstrated that estrogens suppressed the STAT3-mediated transcription activity through ERs. In this study, we examined the effects of EDCs on STAT3-mediated signaling through ERs. Surprisingly, some of EDCs enhanced STAT3-mediated transcription activity through ERs. This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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