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Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
| Title: | Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors. |
| Authors: | Sekine, Yuichi Browse this author | | Yamamoto, Tetsuya Browse this author | | Yumioka, Taro Browse this author | | Imoto, Seiyu Browse this author | | Kojima, Hiroyuki Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | STAT3 | | Cytokine | | Endocrine-disrupting chemicals | | Estrogen receptor | | Transcription |
| Issue Date: | 12-Mar-2004 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 315 |
| Issue: | 3 |
| Start Page: | 692 |
| End Page: | 698 |
| Publisher DOI: | 10.1016/j.bbrc.2004.01.109 |
| PMID: | 14975756 |
| Abstract: | STAT3 mainly acts as a signal transducer of IL-6 family cytokines and transcriptionally activates specific target genes. STAT3 has also been demonstrated to mediate cellular transformation and is found in numerous cancers. Endocrine-disrupting chemicals (EDCs) are a diverse group of chemicals that bind to estrogen receptors (ERs), mimic estrogenic actions, and may have adverse effects on human health. In our previous study, we demonstrated that estrogens suppressed the STAT3-mediated transcription activity through ERs. In this study, we examined the effects of EDCs on STAT3-mediated signaling through ERs. Surprisingly, some of EDCs enhanced STAT3-mediated transcription activity through ERs. This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/28117 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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