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Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
| Title: | Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. |
| Authors: | Sato, Noriko Browse this author | | Yamamoto, Tetsuya Browse this author | | Sekine, Yuichi Browse this author | | Yumioka, Taro Browse this author | | Junicho, Akira Browse this author | | Fuse, Hideki Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | IL-6 | | Heat-shock protein 90 | | Signal transducer and activator of transcription | | Geldanamycin |
| Issue Date: | 24-Jan-2003 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 300 |
| Issue: | 4 |
| Start Page: | 847 |
| End Page: | 852 |
| Publisher DOI: | 10.1016/S0006-291X(02)02941-8 |
| PMID: | 12559950 |
| Abstract: | Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. This inhibitory effect of GA on STAT3 activation was reversed by overexpression of Hsp90. Furthermore, Hsp90 directly bound to STAT3 via its N-terminal region, which interacted with GA. We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/28121 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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