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Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

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タイトル: Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
著者: Sato, Noriko 著作を一覧する
Yamamoto, Tetsuya 著作を一覧する
Sekine, Yuichi 著作を一覧する
Yumioka, Taro 著作を一覧する
Junicho, Akira 著作を一覧する
Fuse, Hideki 著作を一覧する
Matsuda, Tadashi 著作を一覧する
キーワード: IL-6
Heat-shock protein 90
Signal transducer and activator of transcription
発行日: 2003年 1月24日
出版者: Elsevier
誌名: Biochemical and Biophysical Research Communications
巻: 300
号: 4
開始ページ: 847
終了ページ: 852
出版社 DOI: 10.1016/S0006-291X(02)02941-8
抄録: Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. This inhibitory effect of GA on STAT3 activation was reversed by overexpression of Hsp90. Furthermore, Hsp90 directly bound to STAT3 via its N-terminal region, which interacted with GA. We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正


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