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Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

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Title: Cross-talk between bone morphogenic proteins and estrogen receptor signaling.
Authors: Yamamoto, Tetsuya Browse this author
Saatcioglu, Fahri Browse this author
Matsuda, Tadashi3 Browse this author
Authors(alt): 松田, 正3
Issue Date: Jul-2002
Publisher: The Endocrine Society
Journal Title: Endocrinology
Volume: 143
Issue: 7
Start Page: 2635
End Page: 2642
Publisher DOI: 10.1210/endo.143.7.8877
PMID: 12072396
Abstract: Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiological tissue remodeling. Estrogens have key roles in a variety of biological events, such as the development and maintenance of numerous target tissues. Previous studies demonstrated that estrogens suppress BMP functions by repressing BMP gene expression. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP function. BMP-2-induced activation of Sma and Mad (mothers against decapentaplegic)-related protein (Smad) activity and BMP-2-mediated gene expression were suppressed by 17ß-E2 in breast cancer cells and mesangial cells. E2-mediated inhibition of Smad activation was reversed by tamoxifen, an ER antagonist. We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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