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Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

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タイトル: Cross-talk between bone morphogenic proteins and estrogen receptor signaling.
著者: Yamamoto, Tetsuya 著作を一覧する
Saatcioglu, Fahri 著作を一覧する
Matsuda, Tadashi 著作を一覧する
発行日: 2002年 7月
出版者: The Endocrine Society
誌名: Endocrinology
巻: 143
号: 7
開始ページ: 2635
終了ページ: 2642
抄録: Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiological tissue remodeling. Estrogens have key roles in a variety of biological events, such as the development and maintenance of numerous target tissues. Previous studies demonstrated that estrogens suppress BMP functions by repressing BMP gene expression. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP function. BMP-2-induced activation of Sma and Mad (mothers against decapentaplegic)-related protein (Smad) activity and BMP-2-mediated gene expression were suppressed by 17ß-E2 in breast cancer cells and mesangial cells. E2-mediated inhibition of Smad activation was reversed by tamoxifen, an ER antagonist. We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正


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