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Physical and functional interactions between STAT3 and ZIP kinase.
| Title: | Physical and functional interactions between STAT3 and ZIP kinase. |
| Authors: | Sato, Noriko Browse this author | | Kawai, Taro Browse this author | | Sugiyama, Kenji Browse this author | | Muromoto, Ryuta Browse this author | | Imoto, Seiyu Browse this author | | Sekine, Yuichi Browse this author | | Ishida, Masato Browse this author | | Akira, Shizuo Browse this author | | Matsuda, Tadashi Browse this author |
| Keywords: | IL-6 | | LIF | | signal transduction | | STAT3 | | ZIP kinase |
| Issue Date: | Dec-2005 |
| Publisher: | Oxford University Press |
| Journal Title: | International Immunology |
| Volume: | 17 |
| Issue: | 12 |
| Start Page: | 1543 |
| End Page: | 1552 |
| Publisher DOI: | 10.1093/intimm/dxh331 |
| PMID: | 16219639 |
| Abstract: | Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. It plays important roles in cell growth, apoptosis and cell transformation, and is constitutively active in a variety of tumor cells. In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3. ZIPK specifically interacted with STAT3, and did not bind to STAT1, STAT4, STAT5a, STAT5b or STAT6. ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. Small interfering RNA-mediated reduction of ZIPK expression decreased leukemia inhibitory factor (LIF)- and IL-6-induced STAT3-dependent transcription. Furthermore, LIF- and IL-6-mediated STAT3 activation stimulated ZIPK activity. Taken together, our data suggest that ZIPK interacts with STAT3 within the nucleus to regulate the transcriptional activity of STAT3 via phosphorylation of Ser727. |
| Rights: | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version Oxford University Press, International Immunology, 17, 12, 2005, 1543-1552 is available online at: |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/28251 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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