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Physical and functional interactions between STAT3 and ZIP kinase.

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Title: Physical and functional interactions between STAT3 and ZIP kinase.
Authors: Sato, Noriko Browse this author
Kawai, Taro Browse this author
Sugiyama, Kenji Browse this author
Muromoto, Ryuta Browse this author
Imoto, Seiyu Browse this author
Sekine, Yuichi Browse this author
Ishida, Masato Browse this author
Akira, Shizuo Browse this author
Matsuda, Tadashi Browse this author
Keywords: IL-6
signal transduction
ZIP kinase
Issue Date: Dec-2005
Publisher: Oxford University Press
Journal Title: International Immunology
Volume: 17
Issue: 12
Start Page: 1543
End Page: 1552
Publisher DOI: 10.1093/intimm/dxh331
PMID: 16219639
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. It plays important roles in cell growth, apoptosis and cell transformation, and is constitutively active in a variety of tumor cells. In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3. ZIPK specifically interacted with STAT3, and did not bind to STAT1, STAT4, STAT5a, STAT5b or STAT6. ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. Small interfering RNA-mediated reduction of ZIPK expression decreased leukemia inhibitory factor (LIF)- and IL-6-induced STAT3-dependent transcription. Furthermore, LIF- and IL-6-mediated STAT3 activation stimulated ZIPK activity. Taken together, our data suggest that ZIPK interacts with STAT3 within the nucleus to regulate the transcriptional activity of STAT3 via phosphorylation of Ser727.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version Oxford University Press, International Immunology, 17, 12, 2005, 1543-1552 is available online at:
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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