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The immunomodulator FTY720 is phosphorylated and released from platelets

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タイトル: The immunomodulator FTY720 is phosphorylated and released from platelets
著者: Anada, Yoshihiro 著作を一覧する
Igarashi, Yasuyuki 著作を一覧する
Kihara, Akio 著作を一覧する
キーワード: FTY720
Sphingosine 1-phosphate
発行日: 2007年 7月30日
出版者: Elsevier B.V.
誌名: European Journal of Pharmacology
巻: 568
号: 1-3
開始ページ: 106
終了ページ: 111
出版社 DOI: 10.1016/j.ejphar.2007.04.053
抄録: The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 木原 章雄


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