HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

The immunomodulator FTY720 is phosphorylated and released from platelets

Files in This Item:
EJP568-1-3.pdf519.96 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: The immunomodulator FTY720 is phosphorylated and released from platelets
Authors: Anada, Yoshihiro Browse this author
Igarashi, Yasuyuki Browse this author →KAKEN DB
Kihara, Akio Browse this author →KAKEN DB
Keywords: FTY720
Sphingosine 1-phosphate
Issue Date: 30-Jul-2007
Publisher: Elsevier B.V.
Journal Title: European Journal of Pharmacology
Volume: 568
Issue: 1-3
Start Page: 106
End Page: 111
Publisher DOI: 10.1016/j.ejphar.2007.04.053
PMID: 17553484
Abstract: The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木原 章雄

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University