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The immunomodulator FTY720 is phosphorylated and released from platelets

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Title: The immunomodulator FTY720 is phosphorylated and released from platelets
Authors: Anada, Yoshihiro Browse this author
Igarashi, Yasuyuki Browse this author →KAKEN DB
Kihara, Akio Browse this author →KAKEN DB
Keywords: FTY720
Sphingosine 1-phosphate
Sphingolipid
mmunomodulator
Platelet
Issue Date: 30-Jul-2007
Publisher: Elsevier B.V.
Journal Title: European Journal of Pharmacology
Volume: 568
Issue: 1-3
Start Page: 106
End Page: 111
Publisher DOI: 10.1016/j.ejphar.2007.04.053
PMID: 17553484
Abstract: The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters.
Relation: http://www.sciencedirect.com/science/journal/00142999
Type: article (author version)
URI: http://hdl.handle.net/2115/29656
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木原 章雄

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