|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Improvement in Intestinal Coenzyme Q10 Absorption by Food Intake
| Title: | Improvement in Intestinal Coenzyme Q10 Absorption by Food Intake |
| Authors: | OCHIAI, Akiko Browse this author | | ITAGAKI, Shirou Browse this author | | KUROKAWA, Toshimitsu Browse this author | | KOBAYASHI, Masaki Browse this author →KAKEN DB | | HIRANO, Takeshi Browse this author | | ISEKI, Ken Browse this author →KAKEN DB |
| Keywords: | coenzyme | | bioavailability | | food | | emulsion |
| Issue Date: | 2007 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | YAKUGAKU ZASSHI |
| Volume: | 127 |
| Issue: | 8 |
| Start Page: | 1251 |
| End Page: | 1254 |
| Publisher DOI: | 10.1248/yakushi.127.1251 |
| PMID: | 17666877 |
| Abstract: | Coenzyme Q10 (CoQ10) is widely consumed as a food supplement because of its recognition as an important nutrient in supporting human health. Absorption of compounds from the gastrointestinal tract is one of the important determinants of oral bioavailability. However, the absorption of dietary CoQ10 is slow and limited due to its hydrophobicity and large molecular weight. The absorption of orally applied compounds can be enhanced by interactions with food or food components. Thus, we investigated the effect of food intake on the absorption of CoQ10 after oral supplementation. In this study, we demonstrated that food intake enhanced the intestinal absorption of CoQ10. In order to improve intestinal absorption of CoQ10 after oral supplementation, we developed an emulsion formulation. Intestinal absorption of CoQ10 after administration of the emulsion formulation was also enhanced by food intake. Moreover, the peak concentration and the extent of absorption after administration of the emulsion formulation were greater than those after administration of a suspension formulation. It is possible that administration of CoQ10 in an emulsion formulation enhances the pharmacological effects of CoQ10. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/30144 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 井関 健
|
