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Improvement in Intestinal Coenzyme Q10 Absorption by Food Intake

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Title: Improvement in Intestinal Coenzyme Q10 Absorption by Food Intake
Authors: OCHIAI, Akiko Browse this author
ITAGAKI, Shirou Browse this author
KUROKAWA, Toshimitsu Browse this author
KOBAYASHI, Masaki Browse this author →KAKEN DB
HIRANO, Takeshi Browse this author
ISEKI, Ken Browse this author →KAKEN DB
Keywords: coenzyme
bioavailability
food
emulsion
Issue Date: 2007
Publisher: The Pharmaceutical Society of Japan
Journal Title: YAKUGAKU ZASSHI
Volume: 127
Issue: 8
Start Page: 1251
End Page: 1254
Publisher DOI: 10.1248/yakushi.127.1251
PMID: 17666877
Abstract: Coenzyme Q10 (CoQ10) is widely consumed as a food supplement because of its recognition as an important nutrient in supporting human health. Absorption of compounds from the gastrointestinal tract is one of the important determinants of oral bioavailability. However, the absorption of dietary CoQ10 is slow and limited due to its hydrophobicity and large molecular weight. The absorption of orally applied compounds can be enhanced by interactions with food or food components. Thus, we investigated the effect of food intake on the absorption of CoQ10 after oral supplementation. In this study, we demonstrated that food intake enhanced the intestinal absorption of CoQ10. In order to improve intestinal absorption of CoQ10 after oral supplementation, we developed an emulsion formulation. Intestinal absorption of CoQ10 after administration of the emulsion formulation was also enhanced by food intake. Moreover, the peak concentration and the extent of absorption after administration of the emulsion formulation were greater than those after administration of a suspension formulation. It is possible that administration of CoQ10 in an emulsion formulation enhances the pharmacological effects of CoQ10.
Type: article
URI: http://hdl.handle.net/2115/30144
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井関 健

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