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Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament
| Title: | Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament |
| Authors: | Yasuda, Kazunori Browse this author →KAKEN DB | | Sakai, Toshihiko Browse this author | | Kondo, Eiji Browse this author | | Onodera, Shin Browse this author |
| Keywords: | Anterior cruciate ligament | | Bone marrow | | In situ frozen-thawed treatment | | Mechanical properties | | Reconstruction |
| Issue Date: | Oct-2007 |
| Publisher: | Elsevier Ltd. |
| Journal Title: | Clinical Biomechanics |
| Volume: | 22 |
| Issue: | 8 |
| Start Page: | 941 |
| End Page: | 949 |
| Publisher DOI: | 10.1016/j.clinbiomech.2007.05.007 |
| PMID: | 17601640 |
| Abstract: | Background: The purpose of this study is to biomechanically and histologically evaluate the effect of bleeding from bone marrow on remodeling of the in situ frozen-thawed anterior cruciate ligament.
Methods: Forty-four rabbits were used. Eight rabbits were used to evaluate the amount of bleeding at days 1–4. Thirty-six rabbits were divided into two groups, after the right anterior cruciate ligament underwent the freeze-thaw treatment. In Group I, no treatments were applied. In Group II, a tunnel was drilled into the bone marrow the femoral intercondylar notch. Each rabbit was sacrificed at 6 or 12 weeks. We examined the mechanical properties, and the histology of the anterior cruciate ligament. Findings: A small amount of blood clot was observed only on the first day in Group I, while a large amount of blood clot was seen around the anterior cruciate ligament for 3 days after surgery in Group II. In the midsubstance, a number of cells were scattered in Group II, no cells were seen in Group I at 6 weeks. The tangent modulus showed some tendency of difference between Groups I and II at each period. Interpretation:
Bleeding from the bone marrow obviously enhanced extrinsic cell infiltration into the in situ frozen-thawed anterior cruciate ligament at 6 weeks, and showed some effects on its mechanical properties. This study implied that, in anterior cruciate ligament reconstruction, the blood from a bone tunnel play an important role in graft remodeling. |
| Description: | Figure 1-5 are missed. |
| Relation: | http://www.sciencedirect.com/science/journal/02680033 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/30187 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 安田 和則
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