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Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament

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Title: Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament
Authors: Yasuda, Kazunori Browse this author →KAKEN DB
Sakai, Toshihiko Browse this author
Kondo, Eiji Browse this author
Onodera, Shin Browse this author
Keywords: Anterior cruciate ligament
Bone marrow
In situ frozen-thawed treatment
Mechanical properties
Reconstruction
Issue Date: Oct-2007
Publisher: Elsevier Ltd.
Journal Title: Clinical Biomechanics
Volume: 22
Issue: 8
Start Page: 941
End Page: 949
Publisher DOI: 10.1016/j.clinbiomech.2007.05.007
PMID: 17601640
Abstract: Background: The purpose of this study is to biomechanically and histologically evaluate the effect of bleeding from bone marrow on remodeling of the in situ frozen-thawed anterior cruciate ligament. Methods: Forty-four rabbits were used. Eight rabbits were used to evaluate the amount of bleeding at days 1–4. Thirty-six rabbits were divided into two groups, after the right anterior cruciate ligament underwent the freeze-thaw treatment. In Group I, no treatments were applied. In Group II, a tunnel was drilled into the bone marrow the femoral intercondylar notch. Each rabbit was sacrificed at 6 or 12 weeks. We examined the mechanical properties, and the histology of the anterior cruciate ligament. Findings: A small amount of blood clot was observed only on the first day in Group I, while a large amount of blood clot was seen around the anterior cruciate ligament for 3 days after surgery in Group II. In the midsubstance, a number of cells were scattered in Group II, no cells were seen in Group I at 6 weeks. The tangent modulus showed some tendency of difference between Groups I and II at each period. Interpretation: Bleeding from the bone marrow obviously enhanced extrinsic cell infiltration into the in situ frozen-thawed anterior cruciate ligament at 6 weeks, and showed some effects on its mechanical properties. This study implied that, in anterior cruciate ligament reconstruction, the blood from a bone tunnel play an important role in graft remodeling.
Description: Figure 1-5 are missed.
Relation: http://www.sciencedirect.com/science/journal/02680033
Type: article (author version)
URI: http://hdl.handle.net/2115/30187
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安田 和則

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