|Title: ||Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE−/− mice|
|Other Titles: ||Comparison of 99mTc-annexin A5 with 18F-FDG for detecting atherosclerosis in ApoE-/- mice|
|Authors: ||Zhao, Yan Browse this author|
|Kuge, Yuji Browse this author|
|Zhao, Songji Browse this author|
|Morita, Koichi Browse this author|
|Inubushi, Masayuki Browse this author|
|Strauss, H. William Browse this author|
|Blankenberg, Francis G. Browse this author|
|Tamaki, Nagara Browse this author →KAKEN DB|
|Apolipoprotein E-knockout mouse|
|Issue Date: ||Nov-2007|
|Publisher: ||Springer Berlin / Heidelberg|
|Journal Title: ||European Journal of Nuclear Medicine and Molecular Imaging|
|Start Page: ||1747|
|End Page: ||1755|
|Publisher DOI: ||10.1007/s00259-007-0433-2|
|Abstract: ||Purpose: 99mTc-annexin A5, a marker of ongoing apoptosis, and 18F-FDG, a marker of the increased metabolism of inflammatory cells, are supposed to be useful in the detection of metabolically active atheroma. This study reports a comparison of the intralesional distribution of these tracers in relation to lesion development in ApoE−/− mice.
Methods: Male ApoE−/− mice (n = 12–14/group) were maintained on a Western-type diet after the age of 5 weeks. At 25 weeks, 99mTc-annexin A5 or 18F-FDG was injected and the aortas were harvested for autoradiography (ARG) and Oil Red O staining. Regional radioactivity accumulation was compared in relation to the Oil Red O staining score (ranging from 0 to 3, a semiquantitative parameter for evaluating lesion development).
Results: Both 99mTc-annexin A5 and 18F-FDG showed preferential uptake into atherosclerotic lesions, with higher uptake levels for 18F-FDG (mean, 56.07 %ID×kg/m2) than for 99mTc-annexin A5 (mean, 10.38 %ID×kg/m2). The regional uptake levels of each tracer correlated with the Oil Red O staining score (r = 0.65, p < 0.05 for 99mTc-annexin A5; r = 0.56, p < 0.05 for 18F-FDG). The uptake ratios of advanced lesions (score >0.5) to early lesions (score <0.5) were significantly higher for 99mTc-annexin A5 than for 18F-FDG (f = 4.73, p = 0.03).
Conclusion: Both 99mTc-annexin A5 and 18F-FDG accumulate in atherosclerotic lesions and correlate with the severity of each lesion. The higher absolute uptake levels of 18F-FDG may be advantageous for lesion detection, whereas the preferential uptake of 99mTc-annexin A5 in advanced lesions may be a useful indicator of late-stage lesions or vulnerable plaque transformation.|
|Rights: ||The original publication is available at www.springerlink.com|
|Type: ||article (author version)|
|Appears in Collections:||医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)|