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RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells

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タイトル: RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells
その他のタイトル: RNA interference (RNAi) induced by siRNAs modified with 4'-thioribonucleosides incultured mammalian cells
著者: Hoshika, Shuichi 著作を一覧する
Minakawa, Noriaki 著作を一覧する
Kamiya, Hiroyuki 著作を一覧する
Harashima, Hideyoshi 著作を一覧する
Matsuda, Akira 著作を一覧する
キーワード: RNA interference (RNAi)
Short interfering RNA (siRNA)
Chemical modification
4'-thioribonucleoside
4'-thioRNA
発行日: 2005年 6月 6日
出版者: Elsevier B.V.
誌名: FEBS Letters
巻: 579
号: 14
開始ページ: 3115
終了ページ: 3118
出版社 DOI: 10.1016/j.febslet.2005.04.073
抄録: Short interfering RNAs (siRNAs) variously modified with 4'-thioribonucleosides against the Photinus luciferase gene were tested for their induction of the RNA interference (RNAi) activity in cultured NIH/3T3 cells. Results indicated that modifications at the sense-strand were well tolerated for RNAi activity except for full modification with 4'-thioribonucleosides. However, the activity of siRNAs modified at the antisense-strand was dependent on the position and the number of modifications with 4'-thioribonucleosides. Since modifications of siRNAs with 4'-thioribonucleosides were well tolerated in RNAi activity compared with that of 2'-O-methyl nucleosides, 4'-thioribonucleosides might be potentially useful in the development of novel and effective chemically modified siRNAs.
Relation (URI): http://www.sciencedirect.com/science/journal/00145793
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/30353
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 南川 典昭

 

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