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Testicular toxicity of profenofos in matured male rats

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/32319

Title: Testicular toxicity of profenofos in matured male rats
Authors: Moustafa, Gihan Gamal Browse this author
Ibrahim, Zein Shaban Browse this author
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Alkelch, M. Alkelch Browse this author
Sakamoto, Kentaro Q. Browse this author →KAKEN DB
Ishizuka, Mayumi Browse this author →KAKEN DB
Fujita, Shoichi Browse this author →KAKEN DB
Keywords: profenofos
cytochrome P450
testosterone
testis
Issue Date: Dec-2007
Publisher: Springer
Journal Title: Archives of Toxicology
Volume: 81
Issue: 12
Start Page: 875
End Page: 881
Publisher DOI: 10.1007/s00204-007-0217-2
PMID: 17569032
Abstract: To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity.
Rights: The original publication is available at www.springerlink.com
Relation: http://www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/32319
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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