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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Testicular toxicity of profenofos in matured male rats
| Title: | Testicular toxicity of profenofos in matured male rats |
| Authors: | Moustafa, Gihan Gamal Browse this author | | Ibrahim, Zein Shaban Browse this author | | Hashimoto, Yoshiharu Browse this author →KAKEN DB | | Alkelch, M. Alkelch Browse this author | | Sakamoto, Kentaro Q. Browse this author →KAKEN DB | | Ishizuka, Mayumi Browse this author →KAKEN DB | | Fujita, Shoichi Browse this author →KAKEN DB |
| Keywords: | profenofos | | cytochrome P450 | | testosterone | | testis |
| Issue Date: | Dec-2007 |
| Publisher: | Springer |
| Journal Title: | Archives of Toxicology |
| Volume: | 81 |
| Issue: | 12 |
| Start Page: | 875 |
| End Page: | 881 |
| Publisher DOI: | 10.1007/s00204-007-0217-2 |
| PMID: | 17569032 |
| Abstract: | To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity. |
| Rights: | The original publication is available at www.springerlink.com |
| Relation: | http://www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/32319 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石塚 真由美
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