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Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

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タイトル: Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.
著者: Hachiro, Takeru 著作を一覧する
Kawahara, Koichi 著作を一覧する
Sato, Rie 著作を一覧する
Yamauchi, Yoshiko 著作を一覧する
Matsuyama, Daisuke 著作を一覧する
キーワード: fluctuation of contraction rhythm
cardiac myocytes
cardiac fibroblasts
gap junctions
development
発行日: 2007年11月
出版者: Elsevier
誌名: Biosystems
巻: 90
号: 3
開始ページ: 707
終了ページ: 715
出版社 DOI: 10.1016/j.biosystems.2007.02.009
抄録: The heart functions as a syncytium of cardiac myocytes and surrounding supportive non-myocytes such as fibroblasts. There is a possibility that a variety of non-myocyte-derived factors affect the maturation of cardiac myocytes in the development of the heart. Cultured neonatal cardiac myocytes contract spontaneously and cyclically. The fluctuation of beating rhythm varies depending on the strength of coupling through gap junctions among cardiac myocytes, indicating that the development of intercellular communication via gap junctions is crucial to the stability of contraction rhythm in cardiac myocytes. In this study, we aimed at elucidating whether and how cardiac fibroblasts affect the development of cardiac myocytes from the point of view of the changes in the fluctuation of the contraction rhythm of cardiac myocytes in cardiac myocyte-fibroblast co-cultures. The present study suggested that cardiac fibroblasts co-cultured with cardiac myocytes enhanced the intercellular communication among myocytes via gap junctions, thereby stabilizing the spontaneous contraction rhythm of cultured cardiac myocytes.
Relation (URI): http://www.sciencedirect.com/science/journal/03032647
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/32320
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 河原 剛一

 

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