Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

Hachiro, Takeru; Kawahara, Koichi; Sato, Rie; Yamauchi, Yoshiko; Matsuyama, Daisuke

doi:10.1016/j.biosystems.2007.02.009


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Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

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Title:	Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.
Authors:	Hachiro, Takeru Browse this author
	Kawahara, Koichi Browse this author →KAKEN DB
	Sato, Rie Browse this author
	Yamauchi, Yoshiko Browse this author
	Matsuyama, Daisuke Browse this author
Keywords:	fluctuation of contraction rhythm
	cardiac myocytes
	cardiac fibroblasts
	gap junctions
	development
Issue Date:	Nov-2007
Publisher:	Elsevier
Journal Title:	Biosystems
Volume:	90
Issue:	3
Start Page:	707
End Page:	715
Publisher DOI:	10.1016/j.biosystems.2007.02.009
PMID:	17418939
Abstract:	The heart functions as a syncytium of cardiac myocytes and surrounding supportive non-myocytes such as fibroblasts. There is a possibility that a variety of non-myocyte-derived factors affect the maturation of cardiac myocytes in the development of the heart. Cultured neonatal cardiac myocytes contract spontaneously and cyclically. The fluctuation of beating rhythm varies depending on the strength of coupling through gap junctions among cardiac myocytes, indicating that the development of intercellular communication via gap junctions is crucial to the stability of contraction rhythm in cardiac myocytes. In this study, we aimed at elucidating whether and how cardiac fibroblasts affect the development of cardiac myocytes from the point of view of the changes in the fluctuation of the contraction rhythm of cardiac myocytes in cardiac myocyte-fibroblast co-cultures. The present study suggested that cardiac fibroblasts co-cultured with cardiac myocytes enhanced the intercellular communication among myocytes via gap junctions, thereby stabilizing the spontaneous contraction rhythm of cultured cardiac myocytes.
Relation:	http://www.sciencedirect.com/science/journal/03032647
Type:	article (author version)
URI:	http://hdl.handle.net/2115/32320
Appears in Collections:	情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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