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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >
Tolerance Induction in Thymectomized, Adult Xenopus by Co-Transplantation of Thymus and Tolerated Skin Graft
| Title: | Tolerance Induction in Thymectomized, Adult Xenopus by Co-Transplantation of Thymus and Tolerated Skin Graft |
| Authors: | Tozaki, Shizuka Browse this author | | Ono, Masatada Browse this author | | Tochinai, Shin Browse this author →KAKEN DB |
| Issue Date: | Dec-2000 |
| Publisher: | 日本動物学会 |
| Journal Title: | Zoological Science |
| Volume: | 17 |
| Issue: | 9 |
| Start Page: | 1267 |
| End Page: | 1273 |
| Abstract: | In Xenopus, semi-xenogeneic JB skins render donor-specific tolerance to perimetamorphic JJ larvae, whereas the same grafts are never accepted by adults. To clarify the mechanisms underlying tolerance induction, we tried to find a method of inducing tolerance in adults. First, we reconstituted earlythymectomized (E-Txd) adults with larval or adult thymi. All JB skin grafts transplanted to E-Txd adults that had been reconstituted with larval thymi were rejected, while almost all of the E-Txd larvae that had been reconstituted with larval or adult thymi were rendered tolerant. Second, we transplanted tolerated JB (tol-JB) skin, i.e., JB skin that reportedly possessed a suppressive activity (Ono and Tochinai, 1995), to late-thymectomized adults and found that those adults were rendered tolerant. Third, when tol-JB skin and larval or adult thymi were simultaneously transplanted to E-Txd animals, many of the E-Txd adults were rendered tolerant. The overall results indicate that donor-specific tolerance can be induced in thymectomized JJ adults by cotransplanting either a larval or an adult thymus and a tol-JB skin graft. |
| Rights: | (c) 日本動物学会 / 本文献の公開は著者の意思に基づくものである |
| Relation: | http://www.bioone.org/perlserv/?request=get-archive&issn=0289-0003 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/32941 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 栃内 新
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