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DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
| Title: | DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118 |
| Other Titles: | Interactions between ERα and DUSP22 / LMW-DSP2 |
| Authors: | Sekine, Yuichi Browse this author | | Ikeda, Osamu Browse this author | | Hayakawa, Yoshihiro Browse this author | | Tsuji, Satoshi Browse this author | | Imoto, Seiyu Browse this author | | Aoki, Naohito Browse this author | | Sugiyama, Kenji Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | β-estradiol | | estrogen receptor | | phosphatase | | transcriptional regulation | | breast cancer |
| Issue Date: | Sep-2007 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Oncogene |
| Volume: | 26 |
| Issue: | 41 |
| Start Page: | 6038 |
| End Page: | 6049 |
| Publisher DOI: | 10.1038/sj.onc.1210426 |
| PMID: | 17384676 |
| Abstract: | In the previous study, we demonstrated the involvement of dual specificity phosphatase 22 (DUSP22 / LMW-DSP2) in regulating the LIF/IL-6/STAT3-mediated signaling pathway. In this study, we show β-estradiol (E2)-induced DUSP22 mRNA expression in estrogen receptor α (ERα)-positive breast cancer cells, while E2-induced phosphorylation and activation of ERα was suppressed by overexpression of DUSP22 but not catalytically inactive mutants. Furthermore, small-interfering RNA-mediated reduction of DUSP22 expression enhanced ERα-mediated transcription and endogenous gene expression. In fact, DUSP22 associated with ERα in vivo and both endogenous proteins interacted in ERα-positive breast cancer T47D cells. These results strongly suggest that DUSP22 acts as a negative regulator of the ERα-mediated signaling pathway. |
| Relation: | http://www.nature.com/onc/journal/v26/n41/abs/1210426a.html |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/33065 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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