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DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118

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Title: DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118
Other Titles: Interactions between ERα and DUSP22 / LMW-DSP2
Authors: Sekine, Yuichi Browse this author
Ikeda, Osamu Browse this author
Hayakawa, Yoshihiro Browse this author
Tsuji, Satoshi Browse this author
Imoto, Seiyu Browse this author
Aoki, Naohito Browse this author
Sugiyama, Kenji Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: β-estradiol
estrogen receptor
transcriptional regulation
breast cancer
Issue Date: Sep-2007
Publisher: Nature Publishing Group
Journal Title: Oncogene
Volume: 26
Issue: 41
Start Page: 6038
End Page: 6049
Publisher DOI: 10.1038/sj.onc.1210426
PMID: 17384676
Abstract: In the previous study, we demonstrated the involvement of dual specificity phosphatase 22 (DUSP22 / LMW-DSP2) in regulating the LIF/IL-6/STAT3-mediated signaling pathway. In this study, we show β-estradiol (E2)-induced DUSP22 mRNA expression in estrogen receptor α (ERα)-positive breast cancer cells, while E2-induced phosphorylation and activation of ERα was suppressed by overexpression of DUSP22 but not catalytically inactive mutants. Furthermore, small-interfering RNA-mediated reduction of DUSP22 expression enhanced ERα-mediated transcription and endogenous gene expression. In fact, DUSP22 associated with ERα in vivo and both endogenous proteins interacted in ERα-positive breast cancer T47D cells. These results strongly suggest that DUSP22 acts as a negative regulator of the ERα-mediated signaling pathway.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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