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Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats

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Title: Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
Authors: Itagaki, Shirou Browse this author
Chiba, Makoto Browse this author
Kobayashi, Masaki Browse this author
Sugawara, Mitsuru Browse this author
Kobayashi, Michlya Browse this author
Hirano, Takeshi Browse this author
Iseki, Ken Browse this author
Keywords: LEC rats
urinary excretion
transporter
organic anion
urate
Issue Date: Jan-2008
Publisher: Elsevier
Journal Title: Biochimica et Biophysica Acta (BBA). Biomembranes
Volume: 1778
Issue: 1
Start Page: 270
End Page: 275
Publisher DOI: 10.1016/j.bbamem.2007.09.025
Abstract: It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level.
Relation URI: http://www.sciencedirect.com/science/journal/00052736
Type: article (author version)
URI: http://hdl.handle.net/2115/33066
Appears in Collections:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 板垣 史郎

 

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