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Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats

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Title: Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
Authors: Itagaki, Shirou Browse this author
Chiba, Makoto Browse this author
Kobayashi, Masaki Browse this author →KAKEN DB
Sugawara, Mitsuru Browse this author
Kobayashi, Michlya Browse this author
Hirano, Takeshi Browse this author
Iseki, Ken Browse this author →KAKEN DB
Keywords: LEC rats
urinary excretion
organic anion
Issue Date: Jan-2008
Publisher: Elsevier
Journal Title: Biochimica et Biophysica Acta (BBA). Biomembranes
Volume: 1778
Issue: 1
Start Page: 270
End Page: 275
Publisher DOI: 10.1016/j.bbamem.2007.09.025
PMID: 17976528
Abstract: It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 板垣 史郎

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