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Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
| Title: | Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats |
| Authors: | Itagaki, Shirou Browse this author | | Chiba, Makoto Browse this author | | Kobayashi, Masaki Browse this author →KAKEN DB | | Sugawara, Mitsuru Browse this author | | Kobayashi, Michlya Browse this author | | Hirano, Takeshi Browse this author | | Iseki, Ken Browse this author →KAKEN DB |
| Keywords: | LEC rats | | urinary excretion | | transporter | | organic anion | | urate |
| Issue Date: | Jan-2008 |
| Publisher: | Elsevier |
| Journal Title: | Biochimica et Biophysica Acta (BBA). Biomembranes |
| Volume: | 1778 |
| Issue: | 1 |
| Start Page: | 270 |
| End Page: | 275 |
| Publisher DOI: | 10.1016/j.bbamem.2007.09.025 |
| PMID: | 17976528 |
| Abstract: | It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level. |
| Relation: | http://www.sciencedirect.com/science/journal/00052736 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/33066 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 板垣 史郎
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