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Improvement of Force Modulation Mode with Scanning Probe Microscopy for Imaging Viscoelasticity of Living Cells

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Title: Improvement of Force Modulation Mode with Scanning Probe Microscopy for Imaging Viscoelasticity of Living Cells
Authors: Nagayama, Masafumi Browse this author →KAKEN DB
Haga, Hisashi Browse this author →KAKEN DB
Tanaka, Yoshio Browse this author
Hirai, Yoshihiko Browse this author
Kabuto, Masaaki Browse this author
Kawabata, Kazushige Browse this author
Keywords: atomic force microscopy
cell dynamics
mechanical property
elasticity
Young's modulus
viscosity
fibroblast
Issue Date: Jul-2002
Publisher: Japan Society of Applied Physics
Journal Title: Japanese Journal of Applied Physics. Pt. 1, Regular papers, short notes & review papers
Volume: 41
Issue: 7B
Start Page: 4952
End Page: 4955
Publisher DOI: 10.1143/JJAP.41.4952
Abstract: We improved the force modulation mode with scanning probe microscopy (SPM) in order to make a quantitative evaluation of the viscoelasticity of living cells. Taking account of the viscosity of liquid medium, the vibration frequency of the cantilever was selected to be 500 Hz, and analysis of cantilever vibration was adopted for evaluation of the viscoelasticity of the samples. Consequently, we have succeeded in determining viscoelasticity distribution on living cells. The values of Young's modulus and the coefficient of viscosity vary from 10 to 50 kPa and from 20 to 40 Pa·s on a cell, depending on its internal cellular structure.
Rights: Copyright © 2002 The Japan Society of Applied Physics
Type: article (author version)
URI: http://hdl.handle.net/2115/33072
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 永山 昌史

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