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MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

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Title: MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion
Authors: Yamada, Yuma Browse this author →KAKEN DB
Akita, Hidetaka Browse this author
Kamiya, Hiroyuki Browse this author
Kogure, Kentaro Browse this author
Yamamoto, Takenori Browse this author
Shinohara, Yasuo Browse this author
Yamashita, Kikuji Browse this author
Kobayashi, Hideo Browse this author
Kikuchi, Hiroshi Browse this author
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: non-viral vector
mitochondrial drug delivery
membrane fusion
Issue Date: Feb-2008
Publisher: Elsevier
Journal Title: Biochimica et biophysica acta (BBA). Biomembranes
Volume: 1778
Issue: 2
Start Page: 423
End Page: 432
Publisher DOI: 10.1016/j.bbamem.2007.11.002
PMID: 18054323
Abstract: Mitochondria are the principal producers of energy in higher cells. Mitochondrial dysfunction is implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require targeted delivery of therapeutic proteins or nucleic acids to the mitochondria, which will be achieved through innovations in the nanotechnology of intracellular trafficking. Here we describe a liposome-based carrier that delivers its macromolecular cargo to the mitochondrial interior via membrane fusion. These liposome particles, which we call MITO-Porters, carry octaarginine surface modifications to stimulate their entry into cells as intact vesicles (via macropinocytosis). We identified lipid compositions for the MITO-Porter which promote both its fusion with the mitochondrial membrane and the release of its cargo to the intra-mitochondrial compartment in living cells. Thus, the MITO-Porter holds promise as an efficacious system for the delivery of both large and small therapeutic molecules into mitochondria.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 勇磨

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