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KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

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Title: KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
Other Titles: Interactions between STAT1 and KAP1
Authors: Kamitani, Shinya Browse this author
Ohbayashi, Norihiko Browse this author
Ikeda, Osamu Browse this author
Togi, Sumihito Browse this author
Muromoto, Ryuta Browse this author
Sekine, Yuichi Browse this author
Ohta, Kazuhide Browse this author
Ishiyama, Hironobu Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: IFN
transcriptional regulation
Issue Date: 30-May-2008
Publisher: Academic Press
Journal Title: Biochemical and Biophysical Research Communications
Volume: 370
Issue: 2
Start Page: 366
End Page: 370
Publisher DOI: 10.1016/j.bbrc.2008.03.104
PMID: 18381204
Abstract: Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. Recently, we showed that KAP1 is a novel STAT-binding partner that regulates STAT3-mediated transactivation. KAP1 is a universal corepressor protein for the KRAB zinc finger protein superfamily of transcriptional repressors. In this study, we found KAP1-dependent repression of interferon (IFN) /STAT1-mediated signaling. We also demonstrated that endogenous KAP1 associates with endogenous STAT1 in vivo. Importantly, a small-interfering RNA-mediated reduction in KAP1 expression enhanced IFN-induced STAT1-dependent IRF-1 gene expression. These results indicate that KAP1 may act as an endogenous regulator of the IFN/STAT1 signaling pathway.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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