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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression
| Title: | KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression |
| Other Titles: | Interactions between STAT1 and KAP1 |
| Authors: | Kamitani, Shinya Browse this author | | Ohbayashi, Norihiko Browse this author | | Ikeda, Osamu Browse this author | | Togi, Sumihito Browse this author | | Muromoto, Ryuta Browse this author | | Sekine, Yuichi Browse this author | | Ohta, Kazuhide Browse this author | | Ishiyama, Hironobu Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | IFN | | STAT1 | | IRF-1 | | KAP1 | | transcriptional regulation |
| Issue Date: | 30-May-2008 |
| Publisher: | Academic Press |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 370 |
| Issue: | 2 |
| Start Page: | 366 |
| End Page: | 370 |
| Publisher DOI: | 10.1016/j.bbrc.2008.03.104 |
| PMID: | 18381204 |
| Abstract: | Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. Recently, we showed that KAP1 is a novel STAT-binding partner that regulates STAT3-mediated transactivation. KAP1 is a universal corepressor protein for the KRAB zinc finger protein superfamily of transcriptional repressors. In this study, we found KAP1-dependent repression of interferon (IFN) /STAT1-mediated signaling. We also demonstrated that endogenous KAP1 associates with endogenous STAT1 in vivo. Importantly, a small-interfering RNA-mediated reduction in KAP1 expression enhanced IFN-induced STAT1-dependent IRF-1 gene expression. These results indicate that KAP1 may act as an endogenous regulator of the IFN/STAT1 signaling pathway. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/33893 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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