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The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
| Title: | The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction |
| Other Titles: | IL-6 desumoylates PML via SENP1 |
| Authors: | Ohbayashi, Norihiko Browse this author | | Kawakami, Shiho Browse this author | | Muromoto, Ryuta Browse this author | | Togi, Sumihito Browse this author | | Ikeda, Osamu Browse this author | | Kamitani, Shinya Browse this author | | Sekine, Yuichi Browse this author | | Honjoh, Tsutomu Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | IL-6 | | LIF | | SENP1 | | SUMO | | STAT3 | | PML | | transcriptional regulation |
| Issue Date: | 11-Jul-2008 |
| Publisher: | Academic Press |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 371 |
| Issue: | 4 |
| Start Page: | 823 |
| End Page: | 828 |
| Publisher DOI: | 10.1016/j.bbrc.2008.04.179 |
| PMID: | 18474224 |
| Abstract: | Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/33894 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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