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The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/33894

Title: The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction
Other Titles: IL-6 desumoylates PML via SENP1
Authors: Ohbayashi, Norihiko Browse this author
Kawakami, Shiho Browse this author
Muromoto, Ryuta Browse this author
Togi, Sumihito Browse this author
Ikeda, Osamu Browse this author
Kamitani, Shinya Browse this author
Sekine, Yuichi Browse this author
Honjoh, Tsutomu Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: IL-6
LIF
SENP1
SUMO
STAT3
PML
transcriptional regulation
Issue Date: 11-Jul-2008
Publisher: Academic Press
Journal Title: Biochemical and Biophysical Research Communications
Volume: 371
Issue: 4
Start Page: 823
End Page: 828
Publisher DOI: 10.1016/j.bbrc.2008.04.179
PMID: 18474224
Abstract: Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.
Relation: http://www.sciencedirect.com/science/journal/0006291X
Type: article (author version)
URI: http://hdl.handle.net/2115/33894
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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