| Title: | An RNA biding protein, Y14 interacts with and modulates STAT3 activation |
| Other Titles: | Interactions between STAT3 and Y14 |
| Authors: | Ohbayashi, Norihiko Browse this author |
| Taira, Naohisa Browse this author |
| Kawakami, Shiho Browse this author |
| Togi, Sumihito Browse this author |
| Sato, Noriko Browse this author |
| Ikeda, Osamu Browse this author |
| Kamitani, Shinya Browse this author |
| Muromoto, Ryuta Browse this author |
| Sekine, Yuichi Browse this author |
| Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | cytokine |
| STAT3 |
| Y14 |
| RNA-binding protein |
| gene expression |
| signal transduction |
| Issue Date: | 1-Aug-2008 |
| Publisher: | Academic Press |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 372 |
| Issue: | 3 |
| Start Page: | 475 |
| End Page: | 479 |
| Publisher DOI: | 10.1016/j.bbrc.2008.05.073 |
| PMID: | 18503751 |
| Abstract: | Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors via specific tyrosine phosphorylation, dimerization and nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT3 activation, we performed yeast two-hybrid screening. We identified Y14, an RNA-binding protein, as a novel STAT3-binding partner. Y14 bound to STAT3 through the C-terminal region of STAT3 in vivo. Importantly, small-interfering RNA-mediated reduction of endogenous Y14 expression decreased IL-6-induced tyrosine-phosphorylation, nuclear accumulation and DNA binding activity of STAT3, as well as IL-6/STAT3-dependent gene expression. These results indicate that Y14 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing the tyrosine-phosphorylation of STAT3. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/33897 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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