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An RNA biding protein, Y14 interacts with and modulates STAT3 activation

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Title: An RNA biding protein, Y14 interacts with and modulates STAT3 activation
Other Titles: Interactions between STAT3 and Y14
Authors: Ohbayashi, Norihiko Browse this author
Taira, Naohisa Browse this author
Kawakami, Shiho Browse this author
Togi, Sumihito Browse this author
Sato, Noriko Browse this author
Ikeda, Osamu Browse this author
Kamitani, Shinya Browse this author
Muromoto, Ryuta Browse this author
Sekine, Yuichi Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: cytokine
RNA-binding protein
gene expression
signal transduction
Issue Date: 1-Aug-2008
Publisher: Academic Press
Journal Title: Biochemical and Biophysical Research Communications
Volume: 372
Issue: 3
Start Page: 475
End Page: 479
Publisher DOI: 10.1016/j.bbrc.2008.05.073
PMID: 18503751
Abstract: Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors via specific tyrosine phosphorylation, dimerization and nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT3 activation, we performed yeast two-hybrid screening. We identified Y14, an RNA-binding protein, as a novel STAT3-binding partner. Y14 bound to STAT3 through the C-terminal region of STAT3 in vivo. Importantly, small-interfering RNA-mediated reduction of endogenous Y14 expression decreased IL-6-induced tyrosine-phosphorylation, nuclear accumulation and DNA binding activity of STAT3, as well as IL-6/STAT3-dependent gene expression. These results indicate that Y14 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing the tyrosine-phosphorylation of STAT3.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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