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Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes

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Title: Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes
Authors: Kamiya, Hiroyuki Browse this author
Keywords: oxidized DNA precursor
8-hydroxy-dGTP
2-hydroxy-dATP
nucleotide pool sanitization enzyme
Issue Date: 30-Nov-2007
Publisher: 日本環境変異原学会
Journal Title: Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Volume: 29
Issue: 4
Start Page: 133
End Page: 140
Abstract: Base oxidation occurs in the cellular nucleotide pool as well as in DNA, and the oxidized DNA precursors induce mutagenic events. 8-Hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP (2-OH-dATP) have been identified as the major products of in vitro oxidation reactions with Fe2+. The mutagenic potentials of many oxidized DNA precursors have been examined in various experimental systems. Accumulating evidence indicates the importance of 8-OH-dGTP and 2-OH-dATP in the mutation process. In addition, nucleotide pool sanitization enzymes, such as MutT and MTH1, have been identified as a defense against the mutagenesis induced by these oxidized DNA precursors. In this review, the mutagenicities of 8-OH-dGTP and 2-OH-dATP and the functions of MutT-type nucleotide pool sanitization enzymes will be summarized.
Rights: 日本環境変異原学会
本文データは学協会の許諾に基づきCiNiiから複製したものである
(Relation)isversionof: http://ci.nii.ac.jp/naid/110006474277/
Type: article
URI: http://hdl.handle.net/2115/34644
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 紙谷 浩之

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