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Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes
| Title: | Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes |
| Authors: | Kamiya, Hiroyuki Browse this author |
| Keywords: | oxidized DNA precursor | | 8-hydroxy-dGTP | | 2-hydroxy-dATP | | nucleotide pool sanitization enzyme |
| Issue Date: | 30-Nov-2007 |
| Publisher: | 日本環境変異原学会 |
| Journal Title: | Genes and environment : the official journal of the Japanese Environmental Mutagen Society |
| Volume: | 29 |
| Issue: | 4 |
| Start Page: | 133 |
| End Page: | 140 |
| Abstract: | Base oxidation occurs in the cellular nucleotide pool as well as in DNA, and the oxidized DNA precursors induce mutagenic events. 8-Hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP (2-OH-dATP) have been identified as the major products of in vitro oxidation reactions with Fe2+. The mutagenic potentials of many oxidized DNA precursors have been examined in various experimental systems. Accumulating evidence indicates the importance of 8-OH-dGTP and 2-OH-dATP in the mutation process. In addition, nucleotide pool sanitization enzymes, such as MutT and MTH1, have been identified as a defense against the mutagenesis induced by these oxidized DNA precursors. In this review, the mutagenicities of 8-OH-dGTP and 2-OH-dATP and the functions of MutT-type nucleotide pool sanitization enzymes will be summarized. |
| Rights: | 日本環境変異原学会 | | 本文データは学協会の許諾に基づきCiNiiから複製したものである |
| (Relation)isversionof: | http://ci.nii.ac.jp/naid/110006474277/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/34644 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 紙谷 浩之
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