Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice
Title: | Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice |
Authors: | Ikeda, Osamu Browse this author | Sekine, Yuichi Browse this author | Muromoto, Ryuta Browse this author | Ohbayashi, Norihiko Browse this author | Yoshimura, Akihiko Browse this author | Matsuda, Tadashi Browse this author |
Keywords: | signal-transducing adaptor protein-2 | M-CSF | c-Fms | macrophage | wound-healing |
Issue Date: | 1-Sep-2008 |
Publisher: | The Pharmaceutical Society of Japan |
Journal Title: | Biological & Pharmaceutical Bulletin |
Volume: | 31 |
Issue: | 9 |
Start Page: | 1790 |
End Page: | 1793 |
Publisher DOI: | 10.1248/bpb.31.1790 |
Abstract: | Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7. Overexpression of STAP-2 in Raw264.7 cells markedly suppressed M-CSF-induced activation of extracellular signal regulated kinase and Akt. In addition, Raw264.7 overexpressing STAP-2 affected cell migration in wound-healing process. These results suggest that STAP-2 deficiency influences endogenous c-Fms/M-CSF receptor signaling. Here we show that loss of STAP-2 expression in knockout mouse macrophages results in marked enhancement of the c-Fms/M-CSF receptor signaling and wound-healing process. We therefore propose that STAP-2 acts as an endogenous regulator in normal macrophages functions. |
Type: | article |
URI: | http://hdl.handle.net/2115/34686 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 松田 正
|