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Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

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Title: Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice
Authors: Ikeda, Osamu Browse this author
Sekine, Yuichi Browse this author
Muromoto, Ryuta Browse this author
Ohbayashi, Norihiko Browse this author
Yoshimura, Akihiko Browse this author
Matsuda, Tadashi Browse this author
Keywords: signal-transducing adaptor protein-2
M-CSF
c-Fms
macrophage
wound-healing
Issue Date: 1-Sep-2008
Publisher: The Pharmaceutical Society of Japan
Journal Title: Biological & Pharmaceutical Bulletin
Volume: 31
Issue: 9
Start Page: 1790
End Page: 1793
Publisher DOI: 10.1248/bpb.31.1790
Abstract: Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7. Overexpression of STAP-2 in Raw264.7 cells markedly suppressed M-CSF-induced activation of extracellular signal regulated kinase and Akt. In addition, Raw264.7 overexpressing STAP-2 affected cell migration in wound-healing process. These results suggest that STAP-2 deficiency influences endogenous c-Fms/M-CSF receptor signaling. Here we show that loss of STAP-2 expression in knockout mouse macrophages results in marked enhancement of the c-Fms/M-CSF receptor signaling and wound-healing process. We therefore propose that STAP-2 acts as an endogenous regulator in normal macrophages functions.
Type: article
URI: http://hdl.handle.net/2115/34686
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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