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Epstein-Barr virus-derived EBNA2 regulates STAT3 activation

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/35143

Title: Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
Other Titles: Physical and functional interactions between STAT3 and EBNA2
Authors: Muromoto, Ryuta Browse this author
Ikeda, Osamu Browse this author
Okabe, Kanako Browse this author
Togi, Sumihito Browse this author
Kamitani, Shinya Browse this author
Fujimuro, Masahiro Browse this author
Harada, Shizuko Browse this author
Oritani, Kenji Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: STAT3
EBV
EBNA2
LMP1
LIF
transcription
Issue Date: 16-Jan-2009
Publisher: Academic Press
Journal Title: Biochemical and Biophysical Research Communications
Volume: 378
Issue: 3
Start Page: 439
End Page: 443
Publisher DOI: 10.1016/j.bbrc.2008.11.053
PMID: 19032945
Abstract: The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3.
Type: article (author version)
URI: http://hdl.handle.net/2115/35143
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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