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Epstein-Barr virus-derived EBNA2 regulates STAT3 activation
Title: | Epstein-Barr virus-derived EBNA2 regulates STAT3 activation |
Other Titles: | Physical and functional interactions between STAT3 and EBNA2 |
Authors: | Muromoto, Ryuta Browse this author | Ikeda, Osamu Browse this author | Okabe, Kanako Browse this author | Togi, Sumihito Browse this author | Kamitani, Shinya Browse this author | Fujimuro, Masahiro Browse this author | Harada, Shizuko Browse this author | Oritani, Kenji Browse this author | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | STAT3 | EBV | EBNA2 | LMP1 | LIF | transcription |
Issue Date: | 16-Jan-2009 |
Publisher: | Academic Press |
Journal Title: | Biochemical and Biophysical Research Communications |
Volume: | 378 |
Issue: | 3 |
Start Page: | 439 |
End Page: | 443 |
Publisher DOI: | 10.1016/j.bbrc.2008.11.053 |
PMID: | 19032945 |
Abstract: | The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/35143 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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