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Hokkaido University Collection of Scholarly and Academic Papers >
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BART is essential for nuclear retention of STAT3
| Title: | BART is essential for nuclear retention of STAT3 |
| Other Titles: | Interactions between STAT3 and BART |
| Authors: | Muromoto, Ryuta Browse this author | | Sekine, Yuichi Browse this author | | Imoto, Seiyu Browse this author | | Ikeda, Osamu Browse this author | | Okayama, Taichiro Browse this author | | Sato, Noriko Browse this author | | Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | STAT3 | | BART | | IL-6 | | LIF | | nuclear retention | | signal transduction |
| Issue Date: | Mar-2008 |
| Publisher: | Oxford University Press |
| Journal Title: | International Immunology |
| Volume: | 20 |
| Issue: | 3 |
| Start Page: | 395 |
| End Page: | 403 |
| Publisher DOI: | 10.1093/intimm/dxm154 |
| PMID: | 18234692 |
| Abstract: | Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3, for example, is involved in the epithelialmesenchymal transition during gastrulation, organogenesis, wound healing, and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here we identified BART (Binder of ADP-ribosylation factor-like Two) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2. |
| Rights: | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version International Immunology, 20(3), 2008, pp.395-403, is available online at: http://intimm.oxfordjournals.org/cgi/content/full/20/3/395. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/38124 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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