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BART is essential for nuclear retention of STAT3

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Title: BART is essential for nuclear retention of STAT3
Other Titles: Interactions between STAT3 and BART
Authors: Muromoto, Ryuta Browse this author
Sekine, Yuichi Browse this author
Imoto, Seiyu Browse this author
Ikeda, Osamu Browse this author
Okayama, Taichiro Browse this author
Sato, Noriko Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: STAT3
nuclear retention
signal transduction
Issue Date: Mar-2008
Publisher: Oxford University Press
Journal Title: International Immunology
Volume: 20
Issue: 3
Start Page: 395
End Page: 403
Publisher DOI: 10.1093/intimm/dxm154
PMID: 18234692
Abstract: Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3, for example, is involved in the epithelialmesenchymal transition during gastrulation, organogenesis, wound healing, and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here we identified BART (Binder of ADP-ribosylation factor-like Two) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version International Immunology, 20(3), 2008, pp.395-403, is available online at:
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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