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The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation

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Title: The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation
Other Titles: Interactions between Y14, MAGOH and STAT3
Authors: Muromoto, Ryuta Browse this author
Taira, Naohisa Browse this author
Ikeda, Osamu Browse this author
Shiga, Kaname Browse this author
Kamitani, Shinya Browse this author
Togi, Sumihito Browse this author
Kawakami, Shiho Browse this author
Sekine, Yuichi Browse this author
Nanbo, Asuka Browse this author
Oritani, Kenji Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: Cytokine
exon-junction complex
gene expression
signal transduction
Issue Date: 24-Apr-2009
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 382
Issue: 1
Start Page: 63
End Page: 68
Publisher DOI: 10.1016/j.bbrc.2009.02.127
PMID: 19254694
Abstract: Signal transducer and activator of transcription 3 (STAT3), which is activated by cytokines and growth factors, mediates biological actions in many physiological processes. In a previous study, we found that Y14, a core component of the exon-junction complex (EJC) bound to STAT3 and upregulated the transcriptional activity of STAT3 by influencing its DNA-binding activity. In the present study, we demonstrate that STAT3 endogenously interacts with Y14. In addition, we found that MAGOH, a Y14 partner in the EJC, inhibits the STAT3-Y14 complex formation. Furthermore, small-interfering RNA-mediated reduction of MAGOH expression enhanced interleukin-6-induced gene expression. These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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