| Title: | The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation |
| Other Titles: | Interactions between Y14, MAGOH and STAT3 |
| Authors: | Muromoto, Ryuta Browse this author |
| Taira, Naohisa Browse this author |
| Ikeda, Osamu Browse this author |
| Shiga, Kaname Browse this author |
| Kamitani, Shinya Browse this author |
| Togi, Sumihito Browse this author |
| Kawakami, Shiho Browse this author |
| Sekine, Yuichi Browse this author |
| Nanbo, Asuka Browse this author |
| Oritani, Kenji Browse this author |
| Matsuda, Tadashi Browse this author →KAKEN DB |
| Keywords: | Cytokine |
| STAT3 |
| Y14 |
| MAGOH |
| exon-junction complex |
| gene expression |
| signal transduction |
| Issue Date: | 24-Apr-2009 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 382 |
| Issue: | 1 |
| Start Page: | 63 |
| End Page: | 68 |
| Publisher DOI: | 10.1016/j.bbrc.2009.02.127 |
| PMID: | 19254694 |
| Abstract: | Signal transducer and activator of transcription 3 (STAT3), which is activated by cytokines and growth factors, mediates biological actions in many physiological processes. In a previous study, we found that Y14, a core component of the exon-junction complex (EJC) bound to STAT3 and upregulated the transcriptional activity of STAT3 by influencing its DNA-binding activity. In the present study, we demonstrate that STAT3 endogenously interacts with Y14. In addition, we found that MAGOH, a Y14 partner in the EJC, inhibits the STAT3-Y14 complex formation. Furthermore, small-interfering RNA-mediated reduction of MAGOH expression enhanced interleukin-6-induced gene expression. These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/38127 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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