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BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/38441

Title: BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1
Authors: Ikeda, Osamu Browse this author
Sekine, Yuichi Browse this author
Mizushima, Akihiro Browse this author
Oritani, Kenji Browse this author
Yasui, Teruhito Browse this author
Fujimuro, Masahiro Browse this author
Muromoto, Ryuta Browse this author
Nanbo, Asuka Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: EBV
LMP1
BS69
NF-κB
TRADD
Issue Date: 19-May-2009
Publisher: Elsevier
Journal Title: FEBS Letters
Volume: 583
Issue: 10
Start Page: 1567
End Page: 1574
Publisher DOI: 10.1016/j.febslet.2009.04.022
PMID: 19379743
Abstract: Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-κB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-κB activation and up-regulates IL-6 mRNA expression and IκB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).
Type: article (author version)
URI: http://hdl.handle.net/2115/38441
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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