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Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2

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Title: Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
Authors: Ikeda, Osamu Browse this author
Togi, Sumihito Browse this author
Kamitani, Shinya Browse this author
Muromoto, Ryuta Browse this author
Sekine, Yuichi Browse this author
Nanbo, Asuka Browse this author
Fujimuro, Masahiro Browse this author
Matsuda, Tadashi Browse this author →KAKEN DB
Keywords: Epstein-Barr virus
Epstein-Barr nuclear antigen 2
SMRT
STAT3
Issue Date: Jul-2009
Publisher: Pharmaceutical Society of Japan
Journal Title: Biological & pharmaceutical bulletin
Volume: 32
Issue: 7
Start Page: 1283
End Page: 1285
Publisher DOI: 10.1248/bpb.32.1283
Abstract: The Epstein-Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex.
Type: article
URI: http://hdl.handle.net/2115/38801
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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