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Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2

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タイトル: Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
著者: Ikeda, Osamu 著作を一覧する
Togi, Sumihito 著作を一覧する
Kamitani, Shinya 著作を一覧する
Muromoto, Ryuta 著作を一覧する
Sekine, Yuichi 著作を一覧する
Nanbo, Asuka 著作を一覧する
Fujimuro, Masahiro 著作を一覧する
Matsuda, Tadashi 著作を一覧する
キーワード: Epstein-Barr virus
Epstein-Barr nuclear antigen 2
SMRT
STAT3
発行日: 2009年 7月
出版者: Pharmaceutical Society of Japan
誌名: Biological & pharmaceutical bulletin
巻: 32
号: 7
開始ページ: 1283
終了ページ: 1285
出版社 DOI: 10.1248/bpb.32.1283
抄録: The Epstein-Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex.
資料タイプ: article
URI: http://hdl.handle.net/2115/38801
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松田 正

 

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