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Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2
Title: | Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2 |
Authors: | Ikeda, Osamu Browse this author | Togi, Sumihito Browse this author | Kamitani, Shinya Browse this author | Muromoto, Ryuta Browse this author | Sekine, Yuichi Browse this author | Nanbo, Asuka Browse this author | Fujimuro, Masahiro Browse this author | Matsuda, Tadashi Browse this author →KAKEN DB |
Keywords: | Epstein-Barr virus | Epstein-Barr nuclear antigen 2 | SMRT | STAT3 |
Issue Date: | Jul-2009 |
Publisher: | Pharmaceutical Society of Japan |
Journal Title: | Biological & pharmaceutical bulletin |
Volume: | 32 |
Issue: | 7 |
Start Page: | 1283 |
End Page: | 1285 |
Publisher DOI: | 10.1248/bpb.32.1283 |
Abstract: | The Epstein-Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex. |
Type: | article |
URI: | http://hdl.handle.net/2115/38801 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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