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Cardiac Arrest during Gamete Release in Chum Salmon Regulated by the Parasympathetic Nerve System

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Title: Cardiac Arrest during Gamete Release in Chum Salmon Regulated by the Parasympathetic Nerve System
Authors: Makiguchi, Yuya1 Browse this author
Nagata, Shinya2 Browse this author
Kojima, Takahito3 Browse this author
Ichimura, Masaki4 Browse this author
Konno, Yoshifumi5 Browse this author
Murata, Hideki6 Browse this author
Ueda, Hiroshi7 Browse this author →KAKEN DB
Authors(alt): Makiguchi, Y1
Nagata, S2
Kojima, T3
Ichimura, M4
Konno, Y5
Murata, H6
Ueda, H7
Issue Date: 19-Jun-2009
Publisher: Public Library of Science
Journal Title: PLoS ONE
Volume: 4
Issue: 6
Start Page: e5993
Publisher DOI: 10.1371/journal.pone.0005993
Abstract: Cardiac arrest caused by startling stimuli, such as visual and vibration stimuli, has been reported in some animals and could be considered as an extraordinary case of bradycardia and defined as reversible missed heart beats. Variability of the heart rate is established as a balance between an autonomic system, namely cholinergic vagus inhibition, and excitatory adrenergic stimulation of neural and hormonal action in teleost. However, the cardiac arrest and its regulating nervous mechanism remain poorly understood. We show, by using electrocardiogram (ECG) data loggers, that cardiac arrest occurs in chum salmon (Oncorhynchus keta) at the moment of gamete release for 7.39±1.61 s in females and for 5.20±0.97 s in males. The increase in heart rate during spawning behavior relative to the background rate during the resting period suggests that cardiac arrest is a characteristic physiological phenomenon of the extraordinarily high heart rate during spawning behavior. The ECG morphological analysis showed a peaked and tall T-wave adjacent to the cardiac arrest, indicating an increase in potassium permeability in cardiac muscle cells, which would function to retard the cardiac action potential. Pharmacological studies showed that the cardiac arrest was abolished by injection of atropine, a muscarinic receptor antagonist, revealing that the cardiac arrest is a reflex response of the parasympathetic nerve system, although injection of sotalol, a β-adrenergic antagonist, did not affect the cardiac arrest. We conclude that cardiac arrest during gamete release in spawning release in spawning chum salmon is a physiological reflex response controlled by the parasympathetic nervous system. This cardiac arrest represents a response to the gaping behavior that occurs at the moment of gamete release.
Type: article
Appears in Collections:北方生物圏フィールド科学センター (Field Science Center for Northern Biosphere) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 上田 宏

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