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DJ-1 binds to mitochondrial complex I and maintains its activity

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Title: DJ-1 binds to mitochondrial complex I and maintains its activity
Authors: Hayashi, Takuya Browse this author
Ishimori, Chikako Browse this author
Takahashi-Niki, Kazuko Browse this author →KAKEN DB
Taira, Takahiro Browse this author →KAKEN DB
Kim, Yun-chul Browse this author
Maita, Hiroshi Browse this author →KAKEN DB
Maita, Chinatsu Browse this author
Ariga, Hiroyoshi Browse this author →KAKEN DB
Iguchi-Ariga, Sanae M. M. Browse this author →KAKEN DB
Keywords: DJ-1
Parkinson's disease
Complex I
Issue Date: 18-Dec-2009
Publisher: Elsevier Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 390
Issue: 3
Start Page: 667
End Page: 672
Publisher DOI: 10.1016/j.bbrc.2009.10.025
PMID: 19822128
Abstract: Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀 寛芳

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