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DJ-1 binds to mitochondrial complex I and maintains its activity
| Title: | DJ-1 binds to mitochondrial complex I and maintains its activity |
| Authors: | Hayashi, Takuya Browse this author | | Ishimori, Chikako Browse this author | | Takahashi-Niki, Kazuko Browse this author →KAKEN DB | | Taira, Takahiro Browse this author →KAKEN DB | | Kim, Yun-chul Browse this author | | Maita, Hiroshi Browse this author →KAKEN DB | | Maita, Chinatsu Browse this author | | Ariga, Hiroyoshi Browse this author →KAKEN DB | | Iguchi-Ariga, Sanae M. M. Browse this author →KAKEN DB |
| Keywords: | DJ-1 | | Mitochondria | | Parkinson's disease | | Complex I |
| Issue Date: | 18-Dec-2009 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 390 |
| Issue: | 3 |
| Start Page: | 667 |
| End Page: | 672 |
| Publisher DOI: | 10.1016/j.bbrc.2009.10.025 |
| PMID: | 19822128 |
| Abstract: | Parkinson's disease (PD) is caused by neuronal cell death, and oxidative stress and mitochondrial dysfunction are thought to be responsible for onset of PD. DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress. The possible mitochondrial function of DJ-1 has been proposed, but its exact function remains unclear. In this study, we found that DJ-1 directly bound to NDUFA4 and ND1, nuclear and mitochondrial DNA-encoding subunits of mitochondrial complex I, respectively, and was co-localized with complex I and that complex I activity was reduced in DJ-1-knockdown NIH3T3 and HEK293 cells. These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/42484 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 有賀 寛芳
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