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Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis

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Title: Shrinking and development of lipid droplets in adipocytes during catecholamine-induced lipolysis
Authors: Nagayama, Masafumi Browse this author →KAKEN DB
Shimizu, Kyoko Browse this author
Taira, Toshio Browse this author
Uchida, Tsutomu Browse this author
Gohara, Kazutoshi Browse this author
Keywords: Adipocyte
Lipid droplet
Adipose triglyceride lipase (ATGL)
Hormone-sensitive lipase (HSL)
Time-lapse observation
Issue Date: 4-Jan-2010
Publisher: Elsevier B.V.
Journal Title: FEBS Letters
Volume: 584
Issue: 1
Start Page: 86
End Page: 92
Publisher DOI: 10.1016/j.febslet.2009.10.088
PMID: 19896941
Abstract: Time-lapse observation of adipocytes during catecholamine-induced lipolysis clearly shows that shrinking of existing lipid droplets (LDs) occurs in some adipocytes and that small LDs are newly developed in almost all cells. Immunofluorescence imaging reveals that activation and localization of hormone-sensitive lipase (HSL) on the surface of LDs, which are required for conferring maximal lipolysis, are necessary for the shrinking of the LDs. However, not all adipocytes in which phosphorylated HSL is localized on LDs exhibit shrinking of LDs. The simultaneous shrinking and development of LDs yield apparent fragmentation and dispersion of LDs in adipocytes stimulated with catecholamine.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 永山 昌史

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