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Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60

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タイトル: Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60
著者: Hosokawa, Masashi 著作を一覧する
Wanezaki, Satoshi 著作を一覧する
Miyauchi, Kozue 著作を一覧する
Kurihara, Hideyuki 著作を一覧する
Kohno, Hiroyuki 著作を一覧する
Kawabata, Jun 著作を一覧する
Odashima, Shizuo 著作を一覧する
Takahashi, Koretaro 著作を一覧する
キーワード: fucoxanthin
DNA fragmentation
HL-60 cell
発行日: 1999年
出版者: Japanese Society for Food Science and Technology
誌名: Food Science and Technology Research
巻: 5
号: 3
開始ページ: 243
終了ページ: 246
出版社 DOI: 10.3136/fstr.5.243
抄録: The apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
記述: Note
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 高橋 是太郎


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