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Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60

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Title: Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60
Authors: Hosokawa, Masashi Browse this author →KAKEN DB
Wanezaki, Satoshi Browse this author
Miyauchi, Kozue Browse this author
Kurihara, Hideyuki Browse this author →KAKEN DB
Kohno, Hiroyuki Browse this author
Kawabata, Jun Browse this author
Odashima, Shizuo Browse this author
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: fucoxanthin
DNA fragmentation
HL-60 cell
Issue Date: 1999
Publisher: Japanese Society for Food Science and Technology
Journal Title: Food Science and Technology Research
Volume: 5
Issue: 3
Start Page: 243
End Page: 246
Publisher DOI: 10.3136/fstr.5.243
Abstract: The apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
Description: Note
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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