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The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons

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Title: The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons
Authors: Horita, Haruhito Browse this author
Wada, Kazuhiro Browse this author →KAKEN DB
Rivas, Miriam V. Browse this author
Hara, Erina Browse this author
Jarvis, Erich D. Browse this author
Keywords: mkp1
motor pathways
brain organization
neural activity
motor behavior
brain evolution
ring dove
primary sensory
Issue Date: 15-Jul-2010
Publisher: Wiley-Liss
Journal Title: The Journal of Comparative Neurology
Volume: 518
Issue: 14
Start Page: 2873
End Page: 2901
Publisher DOI: 10.1002/cne.22370
Abstract: Many immediate early genes (IEG) have activity-dependent induction in a subset of brain subdivisions or neuron types. However, none have been reported yet with regulation specific to thalamic-recipient sensory input neurons of the telencephalon or in the thalamic sensory input neurons themselves. Here, we report the first such gene, dual specificity phosphatase 1 (dusp1). Dusp1 is an inactivator of mitogen-activated protein kinase (MAPK), and MAPK in turn activates expression of egr1, one of the most commonly studied IEGs, as determined in cultured cells. We found that in the brain of naturally behaving songbirds and other avian species, hearing song, seeing visual stimuli, or performing motor behavior caused high dusp1 up-regulation respectively in auditory, visual, and somatosensory input cell populations of the thalamus and thalamic-recipient sensory input neurons of the telencephalic pallium, whereas high egr1 up-regulation occurred only in subsequently connected secondary and tertiary sensory neuronal populations of these same pathways. Motor behavior did not induce high levels of dusp1 expression in the motor-associated areas adjacent to song nuclei, where egr1 is up-regulated in response to movement. Our analysis of dusp1 expression in mouse brain suggests similar regulation in the sensory input neurons of the thalamus and thalamic-recipient layer IV and IV neurons of the cortex. These findings suggest that dusp1 has specialized regulation to sensory input neurons of the thalamus and telencephalon; they further suggest that this regulation may serve to attenuate stimulus-induced expression of egr1 and other IEGs, leading to unique molecular properties of forebrain sensory input neurons.
Rights: This is the pre-peer-reviewed version of the following article: J. Comp. Neurol. 518:2873–2901, 2010., which has been published in final form at
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 和多 和宏

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