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A volumetric analysis of the brain and hippocampus of rats rendered perinatal hypothyroid

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Title: A volumetric analysis of the brain and hippocampus of rats rendered perinatal hypothyroid
Authors: Hasegawa, Masashi Browse this author
Kida, Ikuhiro Browse this author
Wada, Hiromi Browse this author →KAKEN DB
Keywords: Perinatal hypothyroidism
Thyroid hormone
Hippocampus
Magnetic resonance imaging
Issue Date: 2-Aug-2010
Publisher: Elsevier Ireland
Journal Title: Neuroscience Letters
Volume: 479
Issue: 3
Start Page: 240
End Page: 244
Publisher DOI: 10.1016/j.neulet.2010.05.070
PMID: 20641164
Abstract: The thyroid hormone is essential for the proper development of the central nervous system (CNS). Hormone deficiency during CNS development causes neurological abnormalities in the brain. The hippocampus is one of the brain regions vulnerable to hormone deficiency, and the volume of dentate gyrus and cornu ammonis are reduced by transient hypothyroidism during CNS development. However, it remains unclear whether transient hypothyroidism specifically reduces the whole hippocampal volume. In the present study, we used magnetic resonance imaging (MRI) to examine the effects of perinatal hypothyroidism on the ratio of hippocampal volume to brain volume as well as brain and hippocampal volumes overall. Perinatal hypothyroidism was induced by adding the anti-thyroid drug, methimazole, to the drinking water of pregnant dams from gestational day 15 to postnatal day 21. The MRI experiment was conducted when the rats were between 7 and 11 months old. The results showed reductions of the hippocampal and brain volume of the treated group. However, the ratio of hippocampal volume to brain volume was comparable between the control and treated groups. These results indicate that perinatal hypothyroidism minimizes the brain as a whole, but does not minimize the hippocampus in particular.
Type: article (author version)
URI: http://hdl.handle.net/2115/43889
Appears in Collections:文学院・文学研究院 (Graduate School of Humanities and Human Sciences / Faculty of Humanities and Human Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷川 征史

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