DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc


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FEBSL584-18_3891-3895.pdf

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/44034

Title:	DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc
Authors:	Kim, Yun Chul Browse this author
	Kitaura, Hirotake Browse this author →KAKEN DB
	Iguchi-Ariga, Sanae M. M. Browse this author
	Ariga, Hiroyoshi Browse this author
Keywords:	Simian virus 40
	DJ-1
	Transformation
	p53
Issue Date:	24-Sep-2010
Publisher:	Elsevier B.V.
Journal Title:	FEBS Letters
Volume:	584
Issue:	18
Start Page:	3891
End Page:	3895
Publisher DOI:	10.1016/j.febslet.2010.08.010
PMID:	20708612
Abstract:	Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/44034
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 有賀寛芳

OAI-PMH ( junii2 , jpcoar_1.0 )

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