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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
A neuroeconomic theory of bidirectional synaptic plasticity and addiction
| Title: | A neuroeconomic theory of bidirectional synaptic plasticity and addiction |
| Authors: | Takahashi, Taiki Browse this author →KAKEN DB |
| Issue Date: | Oct-2010 |
| Publisher: | Elsevier |
| Journal Title: | Medical Hypotheses |
| Volume: | 75 |
| Issue: | 4 |
| Start Page: | 356 |
| End Page: | 358 |
| Publisher DOI: | 10.1016/j.mehy.2010.03.029 |
| PMID: | 20395061 |
| Abstract: | Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent findings in neuroeconomics and neurobiology of addiction. Furthermore, it is suggested that several neurobiological substrates such as cortisol (a stress hormone), NMDA and AMPA receptors/subunits and intracellular calcium in the postsynaptic neurons are critical factors determining parameters in Becker and Murphy's economic theory of addiction. Future directions in the application of the theory to studies in neuroeconomics and neuropsychiatry of addiction and its relation to stress at the molecular level are discussed. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44260 |
| Appears in Collections: | 文学院・文学研究院 (Graduate School of Humanities and Human Sciences / Faculty of Humanities and Human Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高橋 泰城
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