HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

Files in This Item:
NCB6-6_408-410.pdf655.15 kBPDFView/Open
SupplementaryTextandFigures.pdfSupplementary Text and Figures2.6 MBPDFView/Open
Please use this identifier to cite or link to this item:

Title: Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms
Authors: Koketsu, Kento Browse this author
Watanabe, Kenji Browse this author
Suda, Haruna Browse this author
Oguri, Hiroki Browse this author
Oikawa, Hideaki Browse this author
Issue Date: Jun-2010
Publisher: Nature Publishing Group
Journal Title: Nature Chemical Biology
Volume: 6
Issue: 6
Start Page: 408
End Page: 410
Publisher DOI: 10.1038/nchembio.365
PMID: 20453862
Abstract: Saframycin A is a potent antitumor antibiotic having unique pentacyclic tetrahydroisoquinoline scaffold. We found that the single nonribosomal peptide synthetase SfmC catalyzes a seven-step transformation from readily synthesized dipeptidyl substrates with long acyl chains into a complex saframycin scaffold. Based on a series of enzymatic reactions, we propose a detailed mechanism involving the reduction of various peptidyl thioesters by an identical R-domain followed by C-domain-mediated Pictet-Spengler reactions in an iterative manner.
Type: article (author version)
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 及川 英秋

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University