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新規アダプタータンパク質STAP-2の免疫シグナルにおける機能
| Title: | 新規アダプタータンパク質STAP-2の免疫シグナルにおける機能 |
| Authors: | Sekine, Yuichi Browse this author |
| Keywords: | signal-transducing adaptor protein-2 (STAP-2) | | adaptor protein | | cytokine | | signal transduction | | immune system |
| Issue Date: | 2010 |
| Journal Title: | Yakugaku Zasshi |
| Volume: | 130 |
| Issue: | 6 |
| Start Page: | 769 |
| End Page: | 775 |
| Publisher DOI: | 10.1248/yakushi.130.769 |
| Abstract: | Signal-transducing adaptor protein-2 (STAP-2) was recently identified as a novel adaptor protein and is a family of STAP adaptor protein and has a variety of functions in cellular signal transductions. Especially STAP-2 has a crucial role in immune systems by controlling cytokine signal transduction. STAP-2 functionally interacts with STAT3 through its YXXQ motif and enhances STAT3 transcriptional activation. In contrast, STAP-2 interacts with STAT5 through its PH and SH2-like domains and decreases STAT5 activity. Importantly, STAP-2 also binds to MyD88 and IKK-α/β and regulates LPS/TLR4 signaling. Moreover, STAP-2 interacts with Epstein-Barr virus-derived LMP1 and modulates LMP1-mediated NF-κB signaling. More importantly, experiments using STAP-2 deficient mice showed that STAP-2 modulated several T-cell functions. T-cells from STAP-2 deficient mice showed enhanced integrin-mediated cell adhesion to fibronectin. Furthermore STAP-2-deficient T-cells show reduced chemotaxis toward SDF-1α. These accumulated evidences indicate that novel adaptor protein STAP-2 plays an important modulator role in both of innate and adaptive immune systems. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/44421 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 関根 勇一
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