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Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

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Title: Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction
Authors: Chen, Yong Mei Browse this author
Kurokawa, Takayuki Browse this author →KAKEN DB
Tominaga, Taiki Browse this author
Yasuda, Kazunori Browse this author →KAKEN DB
Osada, Yoshihito Browse this author →KAKEN DB
Gong, Jian Ping Browse this author →KAKEN DB
Yamamoto, Kimiko Browse this author
Ando, Joji Browse this author
Keywords: Friction
Endothelial cell
Glycocalyx
Gel scaffold
Lubrication
Issue Date: 17-Nov-2010
Publisher: WILEY
Journal Title: Advanced Engineering Materials
Volume: 12
Issue: 11
Start Page: B628
End Page: B636
Publisher DOI: 10.1002/adem.201080021
Abstract: In this study, we investigated the sliding friction of human umbilical vein endothelial cell (HUVEC) monolayer cultured on poly(sodium p-styrene sulfonate) (PNaSS) gel, intending to elucidate the role of the glycocalyx on the surface of endothelial cell (EC) in friction reduction. Three sets of HUVEC monolayers were investigated: 1) as-cultured HUVEC monolayer, 2) HUVEC monolayer treated by transforming growth factor υ1 (TGF-υ1), which increased glycocalyx by 148%, 3) HUVEC monolayer treated by heparinase I, which reduced glycocalyx by 57%, both were compared with that of the as prepared one. When being slid on flat glass surface, the frictional stress of HUVEC monolayer decreased in the order of heparinase I-treated > as-cultured > TGF-υ1-treated samples. The results suggested that glycocalyx may play a role in reducing the friction of endothelial cell monolayer.
Type: article (author version)
URI: http://hdl.handle.net/2115/44824
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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