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Asymmetric Hydrogenation of Aromatic Heterocyclic Ketones Catalyzed by the MsDPEN–Cp*Ir(III) Complex

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Title: Asymmetric Hydrogenation of Aromatic Heterocyclic Ketones Catalyzed by the MsDPEN–Cp*Ir(III) Complex
Authors: Utsumi, Noriyuki Browse this author
Tsutsumi, Kunihiko Browse this author
Watanabe, Masahiko Browse this author
Murata, Kunihiko Browse this author
Arai, Noriyoshi Browse this author
Kurono, Nobuhito Browse this author
Ohkuma, Takeshi Browse this author
Keywords: Asymmetric Hydrogenation
Chiral Alchohol
Enantioselective Reaction
Iridium Catalyst
Ketone
Issue Date: 1-Jan-2010
Publisher: Japan Institute of Heterocyclic Chemistry
Journal Title: Heterocycles
Volume: 80
Issue: 1
Start Page: 141
End Page: 147
Publisher DOI: 10.3987/COM-09-S(S)34
Abstract: Asymmetric hydrogenation of aromatic heterocyclic ketones catalyzed by Cp*Ir(OTf)(Msdpen) (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) affords the heterocyclic alcohols in 93% to > 99% ee. The reaction is conducted in a methanolic solution with a substrate-to-catalyst molar ratio of 200-5000 under 15 atm of H2. The heterocyclic rings of substrates are left intact.
Type: article (author version)
URI: http://hdl.handle.net/2115/45011
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大熊 毅

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