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Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation

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Title: Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: Possible involvement in ovulation
Authors: Fujimori, Chika Browse this author
Ogiwara, Katsueki Browse this author
Hagiwara, Akane Browse this author
Rajapakse, Sanath Browse this author
Kimura, Atsushi Browse this author
Takahashi, Takayuki Browse this author
Keywords: Prostaglandin E2
Cyclooxygenase-2
EP receptor
Gene expression
Ovulation
Medaka
Issue Date: 30-Jan-2011
Publisher: Elsevier Ireland
Journal Title: Molecular and Cellular Endocrinology
Volume: 332
Issue: 1-2
Start Page: 67
End Page: 77
Publisher DOI: 10.1016/j.mce.2010.09.015
PMID: 20932877
Abstract: In vitro ovulation of mature medaka ovarian follicles was inhibited by inhibitors of cyclooxygenase (COX) or by an antagonist of the prostaglandin E2 receptor (EP). Of the three medaka COX genes, ptgs2 was most dominantly expressed in the fish ovary. The ptgs2 transcript was detected in all sizes of growing follicles. In a 24-h spawning cycle, large-sized follicles contained ptgs2 mRNA at a fairly constant level. The levels of COX enzyme activity and prostaglandin E2 were also constant in the large-sized follicles during the spawning cycle. The expression of prostaglandin E2 receptor EP4b (ptger4b) mRNA was drastically upregulated in the large-sized follicles as the ovulation time approached. The current results indicate that prostaglandin E2. which might be produced by COX-2, is involved in the ovulation of medaka, and that EP4b is likely the receptor responsible for exerting the action of prostaglandin E2 in the process.
Type: article (author version)
URI: http://hdl.handle.net/2115/45012
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 孝行

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