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A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells

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Title: A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells
Authors: Ishizuka, Satoshi Browse this author
Saitoh, Ken-ichi Browse this author
Suzuki, Takuya Browse this author
Lee, Jae-Sung Browse this author
Hara, Hiroshi Browse this author
Keywords: Cell proliferation
5-bromo-2'-deoxyuridine
HCT116 cells
Phytate hydrolysate
Issue Date: 15-Apr-2011
Publisher: Elsevier
Journal Title: Food Chemistry
Volume: 125
Issue: 4
Start Page: 1219
End Page: 1225
Publisher DOI: 10.1016/j.foodchem.2010.10.037
Abstract: Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line. IP3-RPH suppresses cell proliferation as well as IP6, and the suppression activity of IP3-RPH was higher than that of IP6. Suppression modes clearly differed between IP3-RPH and IP6. Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6.
Type: article (author version)
URI: http://hdl.handle.net/2115/45248
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 敏

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