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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells
| Title: | A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells |
| Authors: | Ishizuka, Satoshi Browse this author | | Saitoh, Ken-ichi Browse this author | | Suzuki, Takuya Browse this author | | Lee, Jae-Sung Browse this author | | Hara, Hiroshi Browse this author |
| Keywords: | Cell proliferation | | 5-bromo-2'-deoxyuridine | | HCT116 cells | | Phytate hydrolysate |
| Issue Date: | 15-Apr-2011 |
| Publisher: | Elsevier |
| Journal Title: | Food Chemistry |
| Volume: | 125 |
| Issue: | 4 |
| Start Page: | 1219 |
| End Page: | 1225 |
| Publisher DOI: | 10.1016/j.foodchem.2010.10.037 |
| Abstract: | Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line. IP3-RPH suppresses cell proliferation as well as IP6, and the suppression activity of IP3-RPH was higher than that of IP6. Suppression modes clearly differed between IP3-RPH and IP6. Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45248 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石塚 敏
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