|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >
Picosecond time-resolved fluorescence spectroscopy of hematoporphyrin derivative
| Title: | Picosecond time-resolved fluorescence spectroscopy of hematoporphyrin derivative |
| Authors: | Yamashita, Mikio Browse this author | | Nomura, Masahide Browse this author | | Kobayashi, Shunsuke Browse this author | | Sato, Takuzo Browse this author | | Aizawa, Katsuo Browse this author |
| Issue Date: | Dec-1984 |
| Publisher: | IEEE: Institute of Electrical and Electronics Engineers |
| Journal Title: | IEEE Journal of Quantum Electronics |
| Volume: | 20 |
| Issue: | 12 |
| Start Page: | 1363 |
| End Page: | 1369 |
| Publisher DOI: | 10.1109/JQE.1984.1072318 |
| Abstract: | The picosecond time-resolved fluorescence decays I(t) and spectra I(λ, t) for hematoporphyrin derivative (HPD) in a phosphate buffer saline aqueous solution at different concentrations (8.4 x 10^[-6] ～ 8.4 x 10^[-3] M) are measured by a two-dimensional synchroscan streak camera with a mode-locked CW dye laser, and a new emission band (which we call the Y-band) is found at high concentration. It is shown that the fluorescence decays composed of fast and slow components at high concentration are due to the Y-band (120 ps lifetime) from head-to-tail aggregates including equilibrium dimer and stable dimer, and the usual band (3.6 ns lifetime) from monomer, respectively, and the latter band is dynamically quenched by the Förster type resonance energy transfer from the monomer to the aggregate. Furthermore, the measurement of static fluorescence spectra from human gastric cancers and the surrounding in vivo after HPD injection shows that a band corresponding to the Y-band from the aggregate appears at only the cancerous cells. |
| Rights: | © 1984 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/45318 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 山下 幹雄
|
