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PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast


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タイトル: PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast
著者: Obara, Keisuke 著作を一覧する
Ohsumi, Yoshinori 著作を一覧する
発行日: 2011年
出版者: Hindawi Publishing
誌名: Journal of Lipids
巻: 2011
開始ページ: 1
終了ページ: 9
出版社 DOI: 10.1155/2011/498768
抄録: Eukaryotic cells can massively transport their own cytoplasmic contents into a lytic compartment, the vacuole/lysosome, for recycling through a conserved system called autophagy. The key process in autophagy is the sequestration of cytoplasmic contents within a double-membrane structure, the autophagosome. Autophagosome formation requires the elaborate cooperation of Atg (autophagy-related) proteins and lipid molecules. Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase, Vps34, is a key step in coordinating Atg proteins and lipid molecules. Vps34 forms two distinct protein complexes, only one of which is involved in generating autophagic membranes. Upon induction of autophagy, PtdIns(3)P, the enzymatic product of PtdIns 3-kinase, is massively transported into the lumen of the vacuole via autophagy. PtdIns(3)P is enriched on the inner membrane of the autophagosome. PtdIns(3)P recruits the Atg18−Atg2 complex and presumably other Atg proteins to autophagic membranes, thereby coordinating lipid molecules and Atg proteins.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小原 圭介


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