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PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast

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Title: PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast
Authors: Obara, Keisuke Browse this author
Ohsumi, Yoshinori Browse this author
Issue Date: 2011
Publisher: Hindawi Publishing
Journal Title: Journal of Lipids
Volume: 2011
Start Page: 1
End Page: 9
Publisher DOI: 10.1155/2011/498768
Abstract: Eukaryotic cells can massively transport their own cytoplasmic contents into a lytic compartment, the vacuole/lysosome, for recycling through a conserved system called autophagy. The key process in autophagy is the sequestration of cytoplasmic contents within a double-membrane structure, the autophagosome. Autophagosome formation requires the elaborate cooperation of Atg (autophagy-related) proteins and lipid molecules. Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase, Vps34, is a key step in coordinating Atg proteins and lipid molecules. Vps34 forms two distinct protein complexes, only one of which is involved in generating autophagic membranes. Upon induction of autophagy, PtdIns(3)P, the enzymatic product of PtdIns 3-kinase, is massively transported into the lumen of the vacuole via autophagy. PtdIns(3)P is enriched on the inner membrane of the autophagosome. PtdIns(3)P recruits the Atg18−Atg2 complex and presumably other Atg proteins to autophagic membranes, thereby coordinating lipid molecules and Atg proteins.
Rights: http://creativecommons.org/licenses/by-nc-sa/2.1/jp/
Type: article
URI: http://hdl.handle.net/2115/45408
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小原 圭介

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