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Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/45474

Title: Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
Authors: Togi, Sumihito Browse this author
Ikeda, Sumihito Browse this author
Kamitani, Sumihito Browse this author
Nakasuji, Sumihito Browse this author
Sekine, Sumihito Browse this author
Muromoto, Ryuta Browse this author
Nanbo, Asuka Browse this author
Oritani, Kenji Browse this author
Kawai, Taro Browse this author
Akira, Shizuo Browse this author
Matsuda, Tadashi Browse this author
Issue Date: May-2011
Publisher: American Society of Biochemistry and Molecular Biology
Journal Title: Journal of Biological Chemistry
Volume: 286
Issue: 21
Start Page: 19170
End Page: 19177
Publisher DOI: 10.1074/jbc.M110.189829
Abstract: Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in apoptosis and transcriptional regulation. Here, we identified Nemo-like kinase (NLK) as a novel ZIPK-binding partner, and found that ZIPK regulates NLK-mediated repression of canonical Wnt/β−catenin signaling. Indeed, siRNA-mediated reduction of endogenous ZIPK expression reduced Wnt/β−catenin signaling. Furthermore, ZIPK affected complex formation of NLK-T-cell factor (TCF) 4. Importantly, ZIPK siRNA treatment in human colon carcinoma cells resulted in a reduction of β−catenin/TCF-mediated gene expression and cell growth. These results indicate that ZIPK may serve as a transcriptional regulator of canonical Wnt/β−catenin signaling through interaction with NLK/TCF4.
Rights: Copyright ©2011 the American Society for Biochemistry and Molecular Biology
Type: article (author version)
URI: http://hdl.handle.net/2115/45474
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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