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Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4
| Title: | Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4 |
| Authors: | Togi, Sumihito Browse this author | | Ikeda, Sumihito Browse this author | | Kamitani, Sumihito Browse this author | | Nakasuji, Sumihito Browse this author | | Sekine, Sumihito Browse this author | | Muromoto, Ryuta Browse this author | | Nanbo, Asuka Browse this author | | Oritani, Kenji Browse this author | | Kawai, Taro Browse this author | | Akira, Shizuo Browse this author | | Matsuda, Tadashi Browse this author |
| Issue Date: | May-2011 |
| Publisher: | American Society of Biochemistry and Molecular Biology |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 286 |
| Issue: | 21 |
| Start Page: | 19170 |
| End Page: | 19177 |
| Publisher DOI: | 10.1074/jbc.M110.189829 |
| Abstract: | Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in apoptosis and transcriptional regulation. Here, we identified Nemo-like kinase (NLK) as a novel ZIPK-binding partner, and found that ZIPK regulates NLK-mediated repression of canonical Wnt/β−catenin signaling. Indeed, siRNA-mediated reduction of endogenous ZIPK expression reduced Wnt/β−catenin signaling. Furthermore, ZIPK affected complex formation of NLK-T-cell factor (TCF) 4. Importantly, ZIPK siRNA treatment in human colon carcinoma cells resulted in a reduction of β−catenin/TCF-mediated gene expression and cell growth. These results indicate that ZIPK may serve as a transcriptional regulator of canonical Wnt/β−catenin signaling through interaction with NLK/TCF4. |
| Rights: | Copyright ©2011 the American Society for Biochemistry and Molecular Biology |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45474 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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