Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscopy

Okajima, Takaharu; Tanaka, Masaru; Tsukiyama, Shusaku; Kadowaki, Tsubasa; Yamamoto, Sadaaki; Shimomura, Masatsugu; Tokumoto, Hiroshi

doi:10.1143/JJAP.46.5552


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Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscopy

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/45745

Title:	Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscopy
Authors:	Okajima, Takaharu Browse this author →KAKEN DB
	Tanaka, Masaru Browse this author
	Tsukiyama, Shusaku Browse this author
	Kadowaki, Tsubasa Browse this author
	Yamamoto, Sadaaki Browse this author
	Shimomura, Masatsugu Browse this author
	Tokumoto, Hiroshi Browse this author →KAKEN DB
Keywords:	Atomic force microscope
	Living cells
	Stress relaxation
	Viscoelastic properties
	Colloidal probe
Issue Date:	Aug-2007
Publisher:	Japan Society of Applied Physics
Journal Title:	Japanese Journal of Applied Physics
Volume:	46
Issue:	8B
Start Page:	5552
End Page:	5555
Publisher DOI:	10.1143/JJAP.46.5552
Abstract:	We measured the stress relaxation of mouse fibroblast NIH3T3 cells with an atomic force microscope (AFM) using a sharp silicon tip and a silica bead with a radius of ∼1 µm as an indenter. The decay of loading force was clearly observed in NIH3T3 cells at a small initial loading force of ∼0.4 nN and was well fitted to the stretched exponential function rather than to a single exponential function. The stretching exponent parameter was ∼0.5 for both indenters, indicating that the stress relaxation observed in NIH3T3 cells consisted of multiple relaxation processes. The time-domain AFM technique described in this report allows us to measure directly the relaxation process of living cells in a range from milliseconds to seconds.
Relation:	http://jjap.jsap.jp/link?JJAP/46/5552/
Type:	article (author version)
URI:	http://hdl.handle.net/2115/45745
Appears in Collections:	情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡嶋孝治

OAI-PMH ( junii2 , jpcoar_1.0 )

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