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Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake

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タイトル: Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake
著者: Takara, Kazuhiro 著作を一覧する
Hatakeyama, Hiroto 著作を一覧する
Ohga, Noritaka 著作を一覧する
Hida, Kyoko 著作を一覧する
Harashima, Hideyoshi 著作を一覧する
キーワード: Dual-ligand
Active targeting
Cell penetrating peptide
NGR
Tumor endothelial cells
発行日: 2010年 8月30日
出版者: ELSEVIER SCIENCE BV
誌名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
巻: 396
号: 1-2
開始ページ: 143
終了ページ: 148
出版社 DOI: 10.1016/j.ijpharm.2010.05.002
抄録: In this study, a dual-ligand liposomal system comprised of a specific ligand and a cell penetrating peptide (CPP) is described to enhance selectivity and cellular uptake. Dual-ligand PEGylated liposomes were prepared by modifying the end of the PEG with an NGR motif peptide, followed by a surface coating of the liposomes with stearylated oligoarginine (STR-RX) The NGR motif recognizes CD13. a marker protein located on tumor endothelial cells A suitable number of RX units was determined to be R4, since it can be masked by the PEG aqueous layer Although no enhanced cellular uptake was observed when a single modification of PEGylated liposomes with either NGR- or STR-R4 was used, the dual-modification with NGR and STR-R4 stimulated uptake of PEGylated liposomes by CD13 positive cells, and this uptake was superior to that obtained by PEG-unmodified liposomes modified with STR-R4 The dual-ligand system shows a synergistic effect on cellular uptake Collectively, the dual-ligand system promises to be useful in the development efficient and specific drug delivery systems. (C) 2010 Elsevier B V All rights reserved.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/46736
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 畠山 浩人

 

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